| Дата выпуска | 1989 |
| dc.description | 4-Amino-2-Hydroxytoluene is used as a coupler in cosmetic hair dye formulations. The compound has a low oral toxicity in animals and has no significant mutagenic or teratogenic effects. The compound, at most, is a weak skin and eye irritant and, at most, a weak sensitizer. Carcinogenic skin painting studies of hair dyes containing this compound were negative. A variety of epidemio-logic studies have given no indication of a carcinogenic effect from the use of hair dyes. |
| Издатель | SAGE Publications |
| Название | 1 Final Report on the Safety Assessment of 4-Amino-2-Hydroxytoluene |
| Тип | Journal Article |
| DOI | 10.3109/10915818909010523 |
| Electronic ISSN | 1092-874X |
| Print ISSN | 1091-5818 |
| Журнал | International Journal of Toxicology |
| Том | 8 |
| Первая страница | 569 |
| Последняя страница | 587 |
| Выпуск | 4 |
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| Библиографическая ссылка | 24. CTFA. (Oct. 16, 1981). Submission of unpublished data by CTFA. Acute oral toxicity study of 4-Amino-2-Hydroxytoluene in rats. (3–16–3).* |
| Библиографическая ссылка | 25. CTFA. (Dec. 25, 1981). Submission of unpublished data by CTFA. Acute oral toxicity study of 4-Amino-2-Hydroxytoluene in rats. (3–16–4).* |
| Библиографическая ссылка | 26. Schafer, E.W., Jr., Bowles, W.A., Jr., and Hurlbut, J. (1983). The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Arch. Environ. Contam. Toxicol. 12(3), 355–82. |
| Библиографическая ссылка | 27. CTFA. (Nov. 20, 1981). Submission of unpublished data by CTFA. Acute dermal toxicity study of 4-Amino-2-Hydroxytoluene in rabbits. (3–16–6).* ***Available for review: Director, Cosmetic Ingredient Review, 1110 Vermont Ave., N.W., Suite 810, Washington, DC 20005. |
| Библиографическая ссылка | 28. CTFA. (Sept. 28, 1983). Submission of unpublished data by CTFA. Combined 90-day feeding, teratology, dominant lethal and 6-month feeding study on 4-Amino-2-Hydroxytoluene in the Sprague-Dawley rat. Study No. 81/39/021. (3–16–7).* |
| Библиографическая ссылка | 29. CTFA. (Dec. 20, 1979). Submission of unpublished data by CTFA. Evaluation of the skin sensitization potential of 4-Amino-2-Hydroxytoluene in the albino guinea pig. Study No. 79/11/002. (3–16–5).* |
| Библиографическая ссылка | 30. CTFA. (1976). Submission of unpublished data (on 2-methyl resorcinol) by CTFA. Comparable studies of sensitization of different hair dye ingredients. (2–23b-19).* |
| Библиографическая ссылка | 31. CTFA. (Feb. 20, 1986). Submission of unpublished data by CTFA. Photosensitization potential of 4-amino-2-hydroxytoluene and 1-naphthol in guinea pigs. Study No. 85022.* |
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| Библиографическая ссылка | 35. HILL TOP RESEARCH, INC (Nov. 28, 1979). Repeated insult patch test of a medical solution containing 2.0% 4-Amino-2-Hydroxytoluene. Study No. 79–0071–73B. (3–16–1).* |
| Библиографическая ссылка | 36. HILL TOP RESEARCH, INC (Dec. 18, 1979). Repeated insult patch test of a medical solution containing 2.0% 4-Amino-2-Hydroxytoluene. Study No. 79–0072–70B. (3–16–2).* |
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