| Дата выпуска | 1991 |
| dc.description | Hydroxybenzomorpholine (HBM) is a heterocyclic compound that is used in cosmetics as a coupler in coal tar hair dyes. No deaths were reported in a subchronic oral toxicity study in rats. Some degenerative changes in the cortical tubules of the kidneys were observed in the mid and high-dose groups. HBM was considered to be practically nonirritating to the rabbit eye and produced only slight skin irritation. HBM was neither a sensitizer nor a photoallergen. HBM was not mutagenic in either the Ames assay or in the mouse micronucleus test.On the basis of the data included in the report, Hydroxybenzomorpholine is considered to be safe as a hair dye ingredient at the current concentrations of use. |
| Издатель | SAGE Publications |
| Название | Final Report on the Safety Assessment of Hydroxybenzomorpholine |
| Тип | Journal Article |
| DOI | 10.3109/10915819109078630 |
| Electronic ISSN | 1092-874X |
| Print ISSN | 1091-5818 |
| Журнал | International Journal of Toxicology |
| Том | 10 |
| Первая страница | 205 |
| Последняя страница | 213 |
| Выпуск | 1 |
| Библиографическая ссылка | 1. Estrin, N.F., Crosley, P.A., and Haynes, C.R. (Editors). (1982). CTFA Cosmetic Ingredient Dictionary, 3rd ed. Washington, DC: The Cosmetic, Toiletry, and Fragrance Association, p. 127. |
| Библиографическая ссылка | 2. LʼOREAL. (1986). Specification: 6-Hydroxybenzomorpholine /03. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 3. COSMAIR, INC. (1989). UV/Visible analysis spectrum of hydroxybenzomorpholine at use levels. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 4. FOOD AND DRUG ADMINISTRATION (FDA). (1984). Cosmetic product formulation data. FDA computer printout. |
| Библиографическая ссылка | 5. FDA. (1989). Cosmetic product formulation data. FDA computer printout. |
| Библиографическая ссылка | 6. Elder, R.L. (Editor). (1985). Final report on the safety assessment of p-phenylenediamine. J. Am. Coll. Toxicol. 4(3), 203–66. |
| Библиографическая ссылка | 7. FEDERAL REGISTER. (Oct. 16, 1979). Cosmetic product warning statements; coal tar hair dyes containing 4-methoxy-m-phenylenediamine (2,4-diaminoanisole) or 4-methoxy-m-phenylenediamine sulfate (2,4-diaminoanisole sulfate). 44(201), 59509–10. |
| Библиографическая ссылка | 8. Corbett, J.F., and Menkart, J. (1973). Hair coloring. Cutis 12, 190–7. |
| Библиографическая ссылка | 9. LʼOREAL. (1989). Percutaneous penetration of the hair dye Imexine OV on human epidermis placed on Franz type diffusion cells. Assay reference number: 89/02/73. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 10. LʼOREAL. (1989). Percutaneous penetration of the hair dye Imexine OV on human epidermis placed on Franz type diffusion cells. Assay reference number: 89/02/74. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 11. LʼOREAL. (1989). Percutaneous penetration of the hair dye Imexine OV on human epidermis placed on Franz type diffusion cells. Assay reference number: 89/02/75. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 12. LʼOREAL. (1989). Percutaneous penetration of the hair dye Imexine OV on human epidermis placed on Franz type diffusion cells. Assay reference number: 89/02/76. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 13. LʼOREAL. (1989). Evaluation of the toxicity of the compound Imexine OV, administered orally to the rat for 1 month. Study number: 1417 TMR. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 14. LʼOREAL. (1977). Determination of the index of ocular irritation of Imexine OV. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 15. LʼOREAL. (1977). Determination of the index of primary cutaneous irritation of Imexine OV hair dye-solution at 1% in propylene glycol. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 16. IFREB. (1978). Evaluation of the sensitizing potential of a test substance by topical applications in the guinea pig. IFG 58/78, colorant Imexine OV (Chimex). Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 17. HAZELTON-IFT. (1984). Cutaneous phototoxicity and photoallergenicity tests of IFD 57.84 Imexine OV (Lot-Op 45) in the guinea pig. Report no. 407357. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 18. LʼOREAL. (1978). Mutagenic evaluation of the hair dye coupler hydroxy-6-phenomorpholine in the Ames Salmonella typhimurium/microsome plate test. Submission of unpublished data to CTFA. |
| Библиографическая ссылка | 19. LʼOREAL. (1988). Micronucleus test in the mouse. 6-Hydroxybenzomorpholine. Submission of unpublished data to CTFA. |
