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Автор Castro-Gago, Manuel
Автор Eirís-Puñal, Jesús
Автор Novo-Rodríguez, Maria, Inés
Автор Couceiro, José
Автор Camiña, Félix
Автор Rodríguez-Segade, Santiago
Дата выпуска 1998
dc.description Serum levels of free, acyl, and total carnitine were determined in 32 patients with seizures, before and after 3, 6, and 12 months of treatment with valproic acid (17 patients), carbamazepine (10 patients), or phenobarbital (5 patients). In all three treated groups, both free and total carnitine levels showed a significant decline with respect to pretreatment levels. This decline was most marked and most consistent in patients treated with valproic acid. In 35% of the patients in this group, carnitine deficiency (ie, total camitine < 30 μmol/L) was observed by month 12. In none of the three groups were serum carnitine levels significantly correlated with the serum concentration of the drug. These findings suggest a need to monitor serum carnitine levels in children treated with any of these drugs. (J Child Neurol 1998;13:546-549).
Издатель Sage Publications
Название Serum Carnitine Levels in Epileptic Children Before and During Treatment With Valproic Acid, Carbamazepine, and Phenobarbital
Тип Other
DOI 10.1177/088307389801301104
Print ISSN 0883-0738
Журнал Journal of Child Neurology
Том 13
Первая страница 546
Последняя страница 549
Аффилиация Castro-Gago, Manuel, Departamento de Pediatria, Servicio de Neuropediatria, Complejo Hospitalario Universitario de Santiago de Compostela, Hospital General de Galicia
Аффилиация Eirís-Puñal, Jesús, Departamento de Pediatria, Servicio de Neuropediatria, Complejo Hospitalario Universitario de Santiago de Compostela, Hospital General de Galicia
Аффилиация Novo-Rodríguez, Maria, Inés, Departamento de Pediatria, Servicio de Neuropediatria, Complejo Hospitalario Universitario de Santiago de Compostela, Hospital General de Galicia
Аффилиация Couceiro, José, Departamento de Pediatria, Servicio de Neuropediatria, Complejo Hospitalario Universitario de Santiago de Compostela, Hospital General de Galicia
Аффилиация Camiña, Félix, Departamento de Bioquímica y Biologia Molecular, Facultad de Farmacia, Santiago de Compostela Spain
Аффилиация Rodríguez-Segade, Santiago, Departamento de Bioquímica y Biologia Molecular, Facultad de Farmacia, Santiago de Compostela Spain
Выпуск 11
Библиографическая ссылка Ohtani Y., Endo F., Matsuda I.: Carnitine deficiency and hyperammonemia associated with valproic acid therapy . J Pediatr 1982; 101:782-785.
Библиографическая ссылка Laub MC, Paetzke-Brunner I., Jaeger G.: Serum carnitine during valproic acid therapy. Epilepsia1982;27:559-562.
Библиографическая ссылка Bates SR, Hug G.: Carnitine reduction and anticonvulsants in children. Ann Neurol1989;26:468-469.
Библиографическая ссылка Beghi E., Rizzi A., Codegoni AM, et al: Valproate, carnitine metabolism, and biochemical indicators of liver function. Epilepsia1990;31:346-352.
Библиографическая ссылка Opala G., Winter S., Vance C., et al: The effect of valproic acid on plasma carnitine levels. Am J Dis Child1991;145:999-1001.
Библиографическая ссылка Thom H., Carter PE, Cole GF, Stevenson KL: Ammonia and carnitine concentrations in children treated with sodium valproate compared with other anticonvulsant drugs. Dev Med Child Neurol1991;33:795-802.
Библиографическая ссылка Hug G., McGraw CA, Bates SR, Landrigan EA: Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children . J Pediatr 1991;119:799-802.
Библиографическая ссылка Rodríguez-Segade S., Alonso de la Peña C., Tutor JC, et al: Carnitine deficiency associated with anticonvulsant therapy. Clin Chim Acta1989;181:175-182.
Библиографическая ссылка Castro-Gago M., Novo I., Rodriguez-Segade S.: Effects of valproic acid on the urea cycle and carnitine metabolism. Int Pediatr1990;5:54-57.
Библиографическая ссылка Castro-Gago M., Bernabeu FA, Novo I., et al: Efecto de los fármacos anticomiciales sobre el metabolismo renal de la carnitina. Rev Neurol (Barcelona) 1994;22:646-650.
Библиографическая ссылка Nishida N., Sugimoto R., Araki A., et al: Carnitine metabolism in valproate-treated rats: The effect of L-carnitine supplementation. Pediatr Res1987 ;22:500-503.
Библиографическая ссылка Rozas I., Camiña MF, Paz JM, et al: Effects of acute valproate administration on carnitine metabolism in mouse serum and tissues. Biochem Pharmacol1990;39:181-185.
Библиографическая ссылка Camiña F., Rozas I., Castro-Gago M., et al: Alteration of renal carnitine metabolism by anticonvulsant treatment . Neurology 1991; 41:1444-1448.
Библиографическая ссылка Camiña F., Rozas I., Gómez M., et al: Short-term effects of administration of anticonvulsant drugs on free carnitine and acylcarnitine in mouse serum and tissues. Br J Pharmacol1991; 103:1179-1183.
Библиографическая ссылка Mitchell ME : Carnitine metabolism in human subjects. I. Normal metabolism. Am J Clin Nutr 1978;31:293-299.
Библиографическая ссылка Castro-Gago M., Camiña F., Rodriguez-Segade S.: Carnitine deficiency caused by valproic acid, letter. J Pediatr1992;120:496.
Библиографическая ссылка Coulter DL: Carnitine deficiency in epilepsy: Risk factors and treatment. J Child Neurol1995;10(Suppl):2S32-2S39.
Библиографическая ссылка Campos Y., Huertas R., Lorenzo G., et al: Plasma carnitine insufficiency and effectiveness of L-carnitine therapy in patients with mitochondrial myopathy. Muscle Nerve1993;16:150-153.
Библиографическая ссылка Rodríguez-Segade S., Alonso de la Peña C., Paz JM, Del Río R.: Determination of L-carnitine in serum, and implementation on ABA-100 and CentrifiChen 600. Clin Chem1985;31:754-757.
Библиографическая ссылка McGarry JD, Foster DW: An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. J Lipid Res1976 ;17:277-281.
Библиографическая ссылка Zelnik N., Fridkis I., Gruener N.: Reduced carnitine and antiepileptic drugs: Cause relationship or co-existence?Acta Paediatr1995;84:93-95.
Библиографическая ссылка Riva R., Albani F., Gobbi G., et al: Carnitine disposition before and during valproate therapy in patients with epilepsy. Epilepsia1993;34:184-187.
Библиографическая ссылка Schmidt-Sommerfeld E., Werner D., Penn D.: Carnitine plasma concentrations in 353 metabolically healthy children. Eur J Pediatr1988;147:356-360.
Библиографическая ссылка Pons R., De Vivo DC: Primary and secondary carnitine deficiency syndromes. J Child Neurol1995; 10(Suppl):2S8-2S24.
Библиографическая ссылка Komatsu M., Kodoma S., Yokoyama S., et al: Valproate-associated hyperammonemia and DL-carnitine supplement. Kobe J Med Sci 1987;33:81-87.
Библиографическая ссылка Tein I., DiMauro S., Xie Z-W., De Vivo DC: Valproic acid impairs carnitine uptake in cultured human skin fibroblasts: An in vitro model for the pathogenesis of valproic acid associated carnitine deficiency. Pediatr Res1993;34:281-287.

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