Мобильная версия

Доступно журналов:

3 288

Доступно статей:

3 891 637


Скрыть метаданые

Автор Hatcher, J.P.
Автор Boyland, P.
Автор Hagan, J.J.
Дата выпуска 1995
dc.description The effects of the 5-HT<sub> 3</sub> receptor antagonists, granisetron and ondansetron, were investigated on behaviour maintained by intracranial self-stimulation (ICSS). Rats, implanted with bipolar electrodes in the lateral hypothalamus, were trained to lever press on a continuous reinforcement schedule for positively reinforcing trains of electrical stimulation. The frequency at which responding reached 50% of maximum (M50) and the maximum rate of responding (asymptote) were used to measure drug effects. Granisetron (0.01-0.1 mg/kg i.p ) and ondansetron (0.03-0.3 mg/kg i.p ) had no effect on either parameter. In contrast, cocaine (20 mg/kg i.p ) potentiated rewarded responding, reducing M50 values, but neither granisetron (0.01-3.0 mg/kg i.p ) nor ondansetron (0.03-0.3 mg/kg i.p ) blocked this effect. Neither did granisetron (0.1-10.0 mg/kg i.p ) alter the effect of lower doses of cocaine (10 mg/kg i.p.). These data suggest that 5 -HT<sub> 3</sub> receptors do not play a significant role in mediating responding maintained by ICSS in the rat through hypothalamic electrodes. Neither do they modulate cocaine-induced potentiation of the behaviour.
Издатель Sage Publications
Тема intra-cranial self-stimulation
Тема granisetron
Тема ondansetron
Тема cocaine
Тема lateral hypothalamus
Тема rat
Тема reward; reinforcement
Название The 5 -HT3 receptor antagonists, granisetron and ondansetron, do not affect cocaine-induced shifts in intra-cranial self-stimulation thresholds
Тип Journal Article
DOI 10.1177/026988119500900409
Print ISSN 0269-8811
Журнал Journal of Psychopharmacology
Том 9
Первая страница 342
Последняя страница 347
Аффилиация Hatcher, J.P., Psychiatry Research Department, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
Аффилиация Boyland, P., Psychiatry Research Department, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
Аффилиация Hagan, J.J., Psychiatry Research Department, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
Выпуск 4
Библиографическая ссылка Batsche K., Granoff M.I., Wang R.Y. (1992) 5-HT3 receptor antagonists fail to block the suppressant effect of cocaine on the firing rate of A10 dopamine neurones in the rat. Brain Res 592: 273-277
Библиографическая ссылка Blandina P., Goldfarb J., Craddock-Royal B., Green J.P. (1989) Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum. J Pharmacol Exp Ther 251: 803-809
Библиографическая ссылка Bose S., Bailey P.T., Thoa N.B., Pradhan S.N. (1974) Effects of 5-hydroxytryptamine on self-stimulation in rats. Psychopharmacology 36: 255-262
Библиографическая ссылка Carboni E., Acquas E., Leone P., di Chiara G. (1989a) 5-HT3 receptor antagonists block morphine and nicotine but not amphetamine-induced reward. Psychopharmacology 97:1785-1788
Библиографическая ссылка Carboni E., Acquas E., Frau R., Di Chiara G. (1989b) Differential inhibitory effects of a 5-HT 3 antagonist on drug-induced stimulation of dopamine release. Eur J Pharmacol 164: 515-519
Библиографическая ссылка Costall B., Domeney A.M., Naylor R.J., Tyers M.B. (1987) Effects of the 5-HT3 receptor antagonist, GR30832F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset. Br J Pharmacol 92: 881-894
Библиографическая ссылка Crow T.J. (1970) Enhancement by cocaine of intra-cranial self-stimulation in the rat. Life Sci 9: 375-381
Библиографическая ссылка Deakin J F W (1980) On the neurochemical basis of self stimulation with midbrain raphe electrode placements. Pharmacol Biochem Behav 13, 525-530
Библиографическая ссылка Dunn R.W., Carlezon W.A., Corbett R. (1991) Preclinical anxiolytic versus antipsychotic profiles of the 5-HT3 antagonists ondansetron, zacopride, 3α-tropanyl-1H-indole-3-carboxylic acid ester and 1αH, 3α, 5αH-tropan-3-yl-3,5-dichlorobenzoate. Drug Dev Res 23: 289-300
Библиографическая ссылка Esposito R.U., Motola A H D, Kornetsky C. (1978) Cocaine: acute effects on reinforcement thresholds for self-stimulation behaviour to the medial forebrain bundle. Pharmacol Biochem Behav 8: 437-439
Библиографическая ссылка Fibiger H.C. (1978) Drugs and reinforcement mechanisms: a critical review of the catecholamine theory. Annu Rev Pharmacol Toxicol 18: 37-56
Библиографическая ссылка Fozard J.R., Mobaruk A., Li A T M, Newgrosh G. (1979) Blockade of serotonin receptors on autonomic neurones by ( - )cocaine and some related compounds. Eur J Pharmacol 59:195-210
Библиографическая ссылка Gallistel C.R., Karras D. (1984) Pimozide and amphetamine have opposing effects on the reward summation function. Pharmacol Biochem Behav 20: 73-77
Библиографическая ссылка Gilbert D.B., Cooper S.J. (1992) Central 5-HT and reward processes. Adv Biosci 85: 165-178
Библиографическая ссылка Gilbert D.B., Miller J., Greenwood S., Cooper S.J. (1992) Failure to antagonize D-amphetamine's effects with ondansetron, a selective 5-HT3 antagonist. Proceedings of the 7th International Catecholamine Symposium, Amsterdam, Netherlands, 22-26 June
Библиографическая ссылка Greenshaw A.J. (1993) Differential effects of ondansetron, haloperidol and clozapine on electrical self-stimulation of the ventral tegmental area . Behav Pharmacol 4: 479-485
Библиографическая ссылка Gysling K., Wang R.Y. (1983) Morphine-induced activation of A10 dopamine neurones in the rat. Brain Res 277: 119-127
Библиографическая ссылка Hagan R.M., Jones B.J., Jordan C.C., Tyers M.B. (1990) Effect of 5 -HT3 receptor antagonists on responses to selective activation of mesolimbic dopaminergic pathways in the rat. Br J Pharmacol 99: 227-232
Библиографическая ссылка Herberg L.J., De Belleroche J.S., Rose I.C., MontgomeryA M.T. (1992) Effect of the 5-HT3 receptor antagonist ondansetron on hypothalamic self-stimulation in rats and its interaction with the CCK analogue caerulein. Neurosci Lett 140:16-18
Библиографическая ссылка Higgins G.A., Joharchi N., Nguyen P., Sellers E.M. (1992) Effect of the 5-HT3 receptor antagonists, MDL72222 and ondansetron on morphine place conditioning. Psychopharmacology 106: 315-320
Библиографическая ссылка Jiang L.H., Ashby C.R., Kasser R.J., Wang R.Y. (1990) The effect of intraventricular administration of the 5-HT3 receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chroncoulometric study. Brain Res 513: 156-160
Библиографическая ссылка Kilpatrick G.J., Jones B.J., Tyers M.B. (1987) Identification of 5-HT3 receptors in rat brain using radioligand binding. Nature 330: 746-748
Библиографическая ссылка Koob G.F., Fray P.J., Iversen S.J. (1978) Self-stimulation of the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system. Brain Res 146: 123-140
Библиографическая ссылка Lane J.D., Pickering C.L., Hooper M.L., Fagon K., Tyers M.B., Emmett-Oglesby M.W. (1992) failure of ondansetron to block the discriminative or reinforcing properties of cocaine in the rat. Drug Alcohol Depend 30:151-162
Библиографическая ссылка Liebman J.M., Mayer D.J., Liebeskind J.C. (1973) Self-stimulation loci in the midbrain central gray matter of the rat. Behav Biol 9: 299-306
Библиографическая ссылка Montgomery A M J, Rose I.C., Herberg L.J. (1993) The effect of a 5-HT3 receptor antagonist, ondansetron, on brain stimulation reward, and its interaction with direct and indirect stimulants of central dopaminergic transmission. J Neural Transm 91: 1-11
Библиографическая ссылка Morgenson G.J., Takigawa M., Robertson A., Wu M. (1979) Self-stimulation of the nucleus accumbens and ventral tegmental area of Tsai attenuated by microinjections of spiroperidol into the nucleus accumbens. Brain Res 171: 247-259
Библиографическая ссылка Olds J., Milner P. (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J Comp Physiol Psychol 47: 419-427
Библиографическая ссылка Paris J M, Cunningham K.A. (1991) Serotonin 5-HT 3 antagonists do not alter the discriminative stimulus properties of cocaine. Psychopharmacology 104:475-478
Библиографическая ссылка Pei Q., Zetterstrom T., Leslie R.A., Grahame-Smith D.G. (1993) 5-HT3 receptor antagonists inhibit morphine-induced stimulation of mesolimbic dopamine release and function in the rat. Eur J Pharmacol 230: 63-68
Библиографическая ссылка Phillips A.G., Fibiger H.C. (1978) The role of dopamine in maintaining intracranial self-stimulation in the ventral tegmentum, nucleus accumbens, medial and sulcal prefrontal cortices. Can J Psychol 32: 58-66
Библиографическая ссылка Rompre P.P., Miliaressis E. (1985) Pontine and mesencephalic substrates of self-stimulation . Brain Res 359: 246-259
Библиографическая ссылка Rompre P.P., Injoyan R., Hagan J.J. (1995) Effects of granisetron, a 5-HT3 receptor antagonist, on morphine-induced potentiation of brain stimulation reward. Eur J Pharmacol (in press)
Библиографическая ссылка Sorenson S.M., Humphreys T.M., Palfreman M.G. (1989) Effect of acute and chronic MDL73,147EF, a 5-HT 3 receptor antagonist, on A9 and A10 dopamine neurones. Eur J Pharmacol 163:115-118
Библиографическая ссылка van der Hoek G.A., Cooper S.J. (1990) Evidence that ondansetron, a selective 5-HT 3 antagonist, reduces cocaine's psychomotor stimulant effects in the rat. Psychopharmacology 101: S59
Библиографическая ссылка Wise C.D., Berger B.D., Stein L. (1973) Evidence of alpha-noradrenergic reward receptors and serotonergic punishment receptors in the rat brain. Biol Psychiatr 6: 3-22
Библиографическая ссылка Wise R.A., Rompre P. (1989) Brain dopamine and reward. Annu Rev Psychol 40:191-225

Скрыть метаданые