| Автор | Hatcher, J.P. |
| Автор | Boyland, P. |
| Автор | Hagan, J.J. |
| Дата выпуска | 1995 |
| dc.description | The effects of the 5-HT<sub> 3</sub> receptor antagonists, granisetron and ondansetron, were investigated on behaviour maintained by intracranial self-stimulation (ICSS). Rats, implanted with bipolar electrodes in the lateral hypothalamus, were trained to lever press on a continuous reinforcement schedule for positively reinforcing trains of electrical stimulation. The frequency at which responding reached 50% of maximum (M50) and the maximum rate of responding (asymptote) were used to measure drug effects. Granisetron (0.01-0.1 mg/kg i.p ) and ondansetron (0.03-0.3 mg/kg i.p ) had no effect on either parameter. In contrast, cocaine (20 mg/kg i.p ) potentiated rewarded responding, reducing M50 values, but neither granisetron (0.01-3.0 mg/kg i.p ) nor ondansetron (0.03-0.3 mg/kg i.p ) blocked this effect. Neither did granisetron (0.1-10.0 mg/kg i.p ) alter the effect of lower doses of cocaine (10 mg/kg i.p.). These data suggest that 5 -HT<sub> 3</sub> receptors do not play a significant role in mediating responding maintained by ICSS in the rat through hypothalamic electrodes. Neither do they modulate cocaine-induced potentiation of the behaviour. |
| Издатель | Sage Publications |
| Тема | intra-cranial self-stimulation |
| Тема | granisetron |
| Тема | ondansetron |
| Тема | cocaine |
| Тема | lateral hypothalamus |
| Тема | rat |
| Тема | reward; reinforcement |
| Название | The 5 -HT3 receptor antagonists, granisetron and ondansetron, do not affect cocaine-induced shifts in intra-cranial self-stimulation thresholds |
| Тип | Journal Article |
| DOI | 10.1177/026988119500900409 |
| Print ISSN | 0269-8811 |
| Журнал | Journal of Psychopharmacology |
| Том | 9 |
| Первая страница | 342 |
| Последняя страница | 347 |
| Аффилиация | Hatcher, J.P., Psychiatry Research Department, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK |
| Аффилиация | Boyland, P., Psychiatry Research Department, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK |
| Аффилиация | Hagan, J.J., Psychiatry Research Department, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK |
| Выпуск | 4 |
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