| Автор | Quigley, N. |
| Автор | Morgan, D. |
| Автор | Idzikowski, C. |
| Автор | King, D.J. |
| Дата выпуска | 1996 |
| dc.description | Both antipsychotic and anticholinergic drugs have been implicated in the production of the memory deficits seen in schizophrenia. We compared the effects of chlorpromazine (50 mg) and benzhexol (5 mg) with placebo on a battery of tests of memory, psychomotor function and mood, in 12 healthy volunteers. Benzhexol, but not chlorpromazine, impaired both word recall and word recognition. Neither drug had an effect on long-term memory Both active compounds were associated with self-rated sedation, and chlorpromazine produced impairment in saccadic eye movements. This study supports the contention that sedation is unlikely to be the mechanism by which anticholinergic drugs exert their amnestic effect. |
| Издатель | Sage Publications |
| Тема | antipsychotics |
| Тема | anticholinergics |
| Тема | memory |
| Тема | psychomotor performance |
| Тема | eye movements |
| Тема | healthy volunteers |
| Название | The effect of chlorpromazine and benzhexol on memory and psychomotor function in healthy volunteers |
| Тип | Journal Article |
| DOI | 10.1177/026988119601000210 |
| Print ISSN | 0269-8811 |
| Журнал | Journal of Psychopharmacology |
| Том | 10 |
| Первая страница | 146 |
| Последняя страница | 152 |
| Аффилиация | Quigley, N., Department of Therapeutics and Pharmacology, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK |
| Аффилиация | Morgan, D., Department of Therapeutics and Pharmacology, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK |
| Аффилиация | Idzikowski, C., Department of Therapeutics and Pharmacology, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK |
| Аффилиация | King, D.J., Department of Therapeutics and Pharmacology, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK |
| Выпуск | 2 |
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