| Автор | Moncayo, Roy |
| Автор | Moncayo, Helga, E |
| Дата выпуска | 1995 |
| dc.description | We have analysed the levels of gonadotropins in male and female patients with systemic lupus erythematosus (SLE). Human chorionic gonadotropin hCG was elevated in 23.8% of patients compared with 12.7% of controls. hCG isolated from the serum of SLE patients was bioactive in vitro. Levels of hCG were significantly correlated with those of its beta-subunit but not with the levels of follicle stimulating hormone, luteinizing hormone, prolactin alphafetoprotein or carcino embryonic antigen. A high percentage of patients presented an organ-specific humoral immune response against ovarian (26.7%) and endometrial (40%) antigens compared with controls (8% and 7.6%, respectively). Endometrial antibodies were significantly correlated to the levels of prolactin. The ovarian tumour marker CA-125 was elevated in 32.5% of patients, including two males. As a whole, these elements delineate a new endocrine and immunological syndrome in SLE in which the elevation of hCG could provide a central physiological explanation for a series of endocrine alterations that characterize this disease. |
| Издатель | Sage Publications |
| Тема | Systemic lupus erythematosus |
| Тема | Human chorionic gonadotropin |
| Тема | Ovarian autoimmunity |
| Тема | Prolactin |
| Тема | Endometrium |
| Название | A new endocrinological and immunological syndrome in SLE: elevation of human chorionic gonadotropin and of antibodies directed against ovary and endometrium antigens |
| Тип | Journal Article |
| DOI | 10.1177/096120339500400109 |
| Print ISSN | 0961-2033 |
| Журнал | Lupus |
| Том | 4 |
| Первая страница | 39 |
| Последняя страница | 45 |
| Аффилиация | Moncayo, Roy, Departments of Nuclear Medicine and Obstetrics and Gynaecology, University of Innsbruck, A-6020 Innsbruck, Austria |
| Аффилиация | Moncayo, Helga, E, Departments of Nuclear Medicine and Obstetrics and Gynaecology, University of Innsbruck, A-6020 Innsbruck, Austria |
| Выпуск | 1 |
| Библиографическая ссылка | Theofilopoulos AN, Dixon FJMurine models of SLE. Adv Immunol1985; 37: 269-390. |
| Библиографическая ссылка | Roubinian JR , Papoian R., Talal N. Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest 1977; 59: 1066-70. |
| Библиографическая ссылка | Lahita RG, Bradlow HL, Kunkel HG, Fishman J.Alterations of estrogen metabolism in systemic lupus erythematosus. Arthritis Rheum1979; 22: 1195-8. |
| Библиографическая ссылка | Folomeev MI, Dougados M., Beaune J. et al. Plasma sex hormones and aromatase activity in tissues of patients with SLE. Lupus 1992; 1: 191-5. |
| Библиографическая ссылка | Jara LJ, Gomez Sanchez C, Silveira LH, Martinez Osuna P, Vasey FB, Espinoza LRHyperprolactinemia in systemic lupus erythematosus: association with disease activity. Am J Med Sci1992; 303: 222-6. |
| Библиографическая ссылка | McMurray RW, Allen SH, Braun A., Walker SELongstanding hyperprolactinemia (Hyperpr) in systemic lupus erythematosus (SLE): possible hormonal stimulation of an autoimmune syndrome. Arthritis Rheum1992; 35 (Suppl.): S168 (abstract). |
| Библиографическая ссылка | Moncayo-Naveda HE, Moncayo R., Benz R., Wolf A., Lauritzen C.Organ specific antibodies against ovary in patients with systemic lupus erythematosus. Am J Obstet Gynecol1989; 160: 1227-9. |
| Библиографическая ссылка | Moncayo R., Moncayo HESerum levels of CAS-125 are elevated in patients with active systemic lupus erythematosus. Obstet. Gynecol1991; 77: 932-4. |
| Библиографическая ссылка | Irvine WJ, Chan Mmw, Scarth L. et al. Immunological aspects of premature ovarian failure associated with idiopathic Addison's disease. Lancet 1968; ii: 883-7. |
| Библиографическая ссылка | Moncayo HE, Moncayo R., Benz R., Wolf A., Lauritzen C.Ovarian failure and autoimmunity. Detection of autoantibodies directed against both the unoccupied luteinizing hormone/human chorionic gonadotropin receptor and the hormone-receptor complex of bovine corpus luteum. J Clin Invest1989; 84: 1857-65. |
| Библиографическая ссылка | Cameron IT, O'Shea FC, Rolland JM, Hughes EG, de Kretser DM, Healy DL. Occult ovarian failure: a syndrome of infertility, regular menses, and elevated follicle-stimulating hormone concentrations. J Clin Endocrinol Metab1988; 67: 1190-4. |
| Библиографическая ссылка | Moncayo R., Moncayo HE, Dapunt O.Immunological risks of IVF. Lancet1990; i: 180. |
| Библиографическая ссылка | Wilke G., Hinney B., Rath W., Henze C., Wuttke W., Kuhn W.CA-125-Serumspiegel in der Frühschwangerschaft nach hMG/hCGstimulierten und nichstimulierten Zyklen. Geburtsh u Frauenheilk1990; 50: 941-6. |
| Библиографическая ссылка | Jäger W., Diedrich K., Wildt L.Elevated levels of CA-125 in serum of patients suffering from ovarian hyperstimulation syndrome. Fertil Steril1987; 48: 675-8. |
| Библиографическая ссылка | Zeimet AG, Müller-Holzner E., Marth C., Daxenbichler G., Dapunt O.Tumor marker CA-125 in tissues of the female reproductive tract and in serum during the normal menstrual cycle. Fertil Steril1993; 59: 1028-35. |
| Библиографическая ссылка | Moncayo R., Moncayo HEAutoimmune endocrinopathies. 4. The association of autoantibodies directed against ovarian antigens in human disease: a clinical review. J Intern Med1993; 234: 371-8. |
| Библиографическая ссылка | Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the systemic lupus erythematosus . Arthritis Rheum 1982; 25: 1271-7. |
| Библиографическая ссылка | Miller MH, Urowitz MB, Gladman DD, Killinger DWSystemic lupus erythematosus in males. Medicine1983; 62: 327-34. |
| Библиографическая ссылка | Moncayo R., Wilken J., Wilde N., Kann D., Leidenberger F.Anti-endometrial antibodies in endometriosis measured by an enzyme-linked immunosorbent assay before and after treatment with danazol and nafarelin . Obstet Gynecol 1991; 77: 169-70 (letter). |
| Библиографическая ссылка | Perosa F., Carbone R., Ferrone S., Dammacco F.Purification of human immunoglobulins by sequential precipitation with caprylic acid and ammonium sulphate. J Immunol Meth1990; 128: 9-16. |
| Библиографическая ссылка | Mukhopadhyay AK, Bohnet HG, Leidenberger FATestosterone production by mouse Leydig cells is stimulated in vitro by atrial natriuretic factor. FEBS Lett1986; 202: 111-16. |
| Библиографическая ссылка | Dunger DB, Villa AK, Matthews DR et al. Pattern of secretion of bioactive and immunoreactive gonadotropins in normal pubertal children. Clin Endocrinol 1991; 35: 267-75. |
| Библиографическая ссылка | Manasco PK, Girton ME, Diggs RL et al. A novel testis-stimulating factor in familial male precocious puberty. New Engl J Med 1991; 324: 227-31. |
| Библиографическая ссылка | Kletter GB, Padmanabhan V., Brown MB, Reiter EO, Sizonenko PC, Beitins IZSerum bioactive gonadotropins during male puberty: a longitudinal study. J Clin Endocrinol Metab1993; 76: 432-8. |
| Библиографическая ссылка | Beitins IZ, Padmanabhan V.Bioactivity of gonadotropins. Endocrinol Metab Clin North Am1991; 20: 85-120. |
| Библиографическая ссылка | Wall BA, Agudelo CA, Weinblatt ME, Turner RAFalse positive pregnancy tests in SLE. J Rheumatol1982; 9: 303-4. |
| Библиографическая ссылка | Lahita RGThe importance of estrogens in systemic lupus erythematosus. Clin Immunol Immunopathol1992; 63: 17-18. |
| Библиографическая ссылка | Black WP, Goven Adt.Laparoscopy and ovarian biopsy for the assessment of secondary amenorrhea . Am J Obstet Gynecol 1972; 114: 739-47. |
| Библиографическая ссылка | Lavalle C., González-Barcena D., Graef A., Fraga A.Gonadotropin pituitary secretion in systemic lupus erythematosus. Clin Exp Rheumatol1984; 2: 163-5. |
| Библиографическая ссылка | Sequeira JF, Keser G., Greenstein B. et al. Systemic lupus erythematosus: sex hormones in male patients . Lupus 1993; 2: 315-17. |
| Библиографическая ссылка | Kasa Vubu JZ, Padmanabhan V., Kletter GB et al. Serum bioactive luteinizing and follicle-stimulating hormone concentrations in girls increase during puberty. Pediatr Res 1993; 34: 829-33. |
| Библиографическая ссылка | Crosignani PG , Maini MC, Negri E., Ragni G. Human prolactin release induced by follicle stimulating hormone and human chorionic gonadotropin. Hum Reprod 1991; 6: 1070-3. |
| Библиографическая ссылка | Athreya BH, Pletcher J., Zulian F., Weiner DM, Williams W.Subset-specific effects of sex hormones and pituitary gonadotropins on human lymphocyte proliferation in vitro. Clin Immunol Immunopathol1993; 66: 201-11. |
| Библиографическая ссылка | Moncayo R., Moncayo HEAutoimmunity and the ovary. Immunol Today1992; 13: 255-8. |
| Библиографическая ссылка | Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 46-1986. A 26-year-old woman with secondary amenorrhea. New Engl J Med1986; 315: 1336-43. |
| Библиографическая ссылка | Bannatyne P. , Russell P., Shearman RP Autoimmune oophoritis: a clinicopathologic assessment of 12 cases. Int J Gynecol Pathol 1990; 9: 191-207. |
| Библиографическая ссылка | Arnalich F. , Benito-Urbina S., Gonzalez-Gancedo P., Iglesias E., de Miguel E., Gijon Banos J. Inadequate production of progesterone in women with systemic lupus erythematosus. Br J Rheumatol 1992; 31: 247-51. |
| Библиографическая ссылка | Meyer WR, Lavy G., DeCherney AH, Visintin I., Economy K., Luborsky JLEvidence of gonadal and gonadotropin antibodies in women with suboptimal ovarian response to exogenous gonadotropin. Obstet Gynecol1990; 75: 795-9. |
| Библиографическая ссылка | Uibo R., Aavik E.Peterson P. et al. Autoantibodies to cytochrome P450 enzymes P450scc, P450c 17 and P450c21 in autoimmune poly-glandular disease types I and II and in isolated Addison's disease. J Clin Endocrinol Metab 1994; 78: 323-8. |
| Библиографическая ссылка | Pekonen F., Siegberg R., Mäkinen T., Miettinen A., Yli-Korkala O.Immunological disturbances in patients with premature ovarian failure. Clin Endocrinol1986; 25: 1-6. |
| Библиографическая ссылка | Martínez-Cordero E., Hernández-Bueno A., Romo J., Reyes López PA, Porias Cuéllar H., Katona Salo G.Lupus eritematoso generalizado. Estudio hormonal en pacientes con amenorrea secundaria. Rev Invest Clin1985; 37: 113-18. |
| Библиографическая ссылка | Rabinowe SL , Berger MJ, Welch WR, Dluhy RG Lymphocyte dysfunction in autoimmune oophoritis. Resumption of menses with corticosteroids. Am J Med 1986; 81: 347-50. |
| Библиографическая ссылка | Sotsiou F., Bottazzo GF, Doniach D.Immunofluorescence studies on autoantibodies to steroid-producing cells and to germline cells in endocrine disease and infertility. Clin Exp Immunol1980; 39: 97-111. |
| Библиографическая ссылка | Hughes ER, Ely RS, Kelley VCPlasma adrenocortical hormones in connective tissue diseases. Am J Dis Child1962; 104: 610-13. |
| Библиографическая ссылка | Del Rey A., Besedovsky HO, Sorkin E.Endogenous blood levels of corticosterone control the immunologic cell mass and B cell activity in mice. J Immunol1984 ; 133: 572-5. |
| Библиографическая ссылка | Morrow Wjw, Youinou P., Isenberg DA, Snaith.Systemic lupus erythematosus: 25 years of treatment related to immunopathology. Lancet1983; ii: 206-10. |
| Библиографическая ссылка | Fedele L., Arcaini L., Baglioni A., Bianchi S., Menard S.What is the source of elevated serum levels of CA 125 in patients with endometriosis?Eur J Obstet Gynecol Reprod Biol1989; 129: 158-68. |
| Библиографическая ссылка | Gellersen B. , Bonhoff A., Hunt N., Bohnet HG Decidual-type prolactin expression by the human myometrium. Endocrinology 1991; 129: 158-68. |
| Библиографическая ссылка | Bast RC, Klug TL, St. John E. et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. New Engl J Med 1983; 309: 883-7. |
| Библиографическая ссылка | Matsuda T., Hida S., Yoshida O.Prostatic adenocarcinoma with endometrioid features treated with oestrogen . Br J Urol 1989; 64: 317-18. |
| Библиографическая ссылка | Moncayo HE, Sölder E., Abfalter E., Moncayo R.Cytokines and the maternal-fetal interface: serum levels of IL2 and sIL-2R during pregnancy and parturition. Immunol Today1994; 15: 295. |
| Библиографическая ссылка | Moncayo-Naveda HE, Moncayo R., Benz R., Wolf A., Lauritzen C.Freies T8-Antigen und lösliches Interleukin-2-Rezeptormolekül bei Patientinnen mit Sterilität. Gynäkol Rundsch1988; 28: 34-5. |
| Библиографическая ссылка | Matsuura S. , Ohashi M., Chen HC et al. Physicochemical and immunological characterization of an HCG-like substance from human pituitary glands. Nature 1980; 286: 741-1. |
| Библиографическая ссылка | Hoermann R. , Spoettl G., Moncayo R., Mann K. Evidence for the presence of human chorionic gonadotropin (hCG) and free β-subunit of hCG in the human pituitary. J Clin Endocrinol Metab 1990; 71: 179-86. |
| Библиографическая ссылка | Conn PM, Crowley WFGonadotropin-releasing hormone and its analogues. New Engl J Med1991; 324: 93-103. |
| Библиографическая ссылка | Catania A., Mangone I., Motta P., Zanussi C.Administration of gonadotropin-releasing hormone analog as adjunctive therapy in women with systemic lupus erythematosus. Arthritis Rheum1989; 32: 1186-8. |
| Библиографическая ссылка | Contratto AW , Levine S. Acute lupus erythematosus disseminatus. Report of a case. New Engl J Med 1939; 221: 602-4. |
