| Автор | Eriksen, Stuart |
| Автор | Keller, L., Robin |
| Дата выпуска | 1993 |
| dc.description | Both the selection of doses of pharmaceutical agents and comparisons between pharma ceutical agents have long been based on the nonquantified concept of the risk-benefit ratio. Though useful, this concept implies a data comparison that is difficult to make: the toxicity versus the efficacy of a drug compound. This research demonstrates an approach for weigh ing risks and benefits by combining utility functions for human efficacy and toxicity with animal and laboratory toxicity information to develop an overall multiattribute utility function for an ophthalmic pharmaceutical agent, I-bunolol, intended for the treatment of glaucoma. With this multiattribute function and a small portion of the published data available for this drug, the expected utilities for six doses (including a control) could be compared and the value of this approach in drug-dosage selection demonstrated. Key words: decision analysis; expected utility; dosage selection; compound comparison; pharmaceutical decision; mul tiattribute utility; risk-benefit ratio. (Med Decis Making 1993;13:118-125) |
| Издатель | Sage Publications |
| Название | A Multiattribute-utility-function Approach to Weighing the Risks and Benefits of Pharmaceutical Agents |
| Тип | Journal Article |
| DOI | 10.1177/0272989X9301300205 |
| Print ISSN | 0272-989X |
| Журнал | Medical Decision Making |
| Том | 13 |
| Первая страница | 118 |
| Последняя страница | 125 |
| Выпуск | 2 |
| Библиографическая ссылка | New Drug Law, 21 USC Section 102(c) of the Drug Amendments of 1962. Amending Section 505(d) (21USC 355(d)) of the 1938 Act. |
| Библиографическая ссылка | Kolker AE, Hetherington J.Medical techniques: diagnosis and therapy of the glaucomas, 5th ed. St. Louis: C. V. Mosby, 1983. |
| Библиографическая ссылка | Lesar T.Drug review: comparison of topical glaucoma therapy. Clin Pharm.1987;6:451-63. |
| Библиографическая ссылка | Novack GDOn cardiovascular effects of topical glaucoma therapy. J Toxicol; Cutaneous and Ocular Toxicol.1984;3:243-50. |
| Библиографическая ссылка | Keeney RL, Raiffa H.Decisions with multiple objectives: preferences and value tradeoffs . New York: John Wiley and Sons , 1976 . |
| Библиографическая ссылка | Long D., Zimmerman T., Spaeth G., et al. Minimum concentration of levobunolol required to control intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension , Am J Ophthalmol. 1985;99:18-22. |
| Библиографическая ссылка | Moskowitz AJ , Pauker SG A patient with new Q waves: methods for decision making in the individual patient. J Am Coll Cardiol. 1989;14(3):29A-37A. |
| Библиографическая ссылка | Partamian LG , Kass MA, Gordon M. Dose + response study of the effect of levobunolol on ocular hypertension. Am J Ophthalmol. 1986 ;95:229-32. |
| Библиографическая ссылка | Keeney RL, Sarin RK, Winkler RLAnalysis of alternative national ambient carbon monoxide standards . Manage Sci. 1984;30:518-28. |
| Библиографическая ссылка | Fishburn PCMethods of estimating additive utilities. Manag Sci.1967;13:435-53. |
| Библиографическая ссылка | Eriksen S.Decision making with information from apparently non-comparable studies . Dissertation, University Microfilms International. 300 N. Zeeb Road, Ann Arbor, MI 48106. |
| Библиографическая ссылка | Kassirer JP , Moskowitz AJ, Lau J., et al. Decision analysis: a progress report . Ann Intern Med. 1987;106:275-91. |
| Библиографическая ссылка | Jacoby I., Pauker SGTechnology assessment in health care: group process and decision theory . Israel J Med Sci. 1986:22(3-4):183-90. |
| Библиографическая ссылка | Patrick DL, Bush JW, Chen MMToward an operational definition of health. J Health Soc Behav.1973;14:6-23. |
| Библиографическая ссылка | Patrick DL, Bush JW, Chen MMMethods for measuring levels of well-being for a health-status index. Health Ser Res.1973;8:228-45. |
| Библиографическая ссылка | Pauker SGCoronary artery surgery: the use of decision analysis. Ann Intern Med.1976;85:8-18. |
| Библиографическая ссылка | Young MJ, Fried LS, Eisenberg JM, et al. The single-cutoff trap: implications for Bayesian analysis of stress electrocardiograms. Med Decis Making.1989;9:176-80. |
| Библиографическая ссылка | Spetzler CSThe development of a corporate risk policy for capital investment decisions. IEEE Trans Sys Cybern.1968;SSC-4279-300. |
