| Автор | Peters, AR |
| Автор | Geelen, JAG |
| Автор | denBoer, JA |
| Автор | Prevo, RL |
| Автор | Minderhoud, JM |
| Автор | ʼs-Gravenmade, EJ |
| Дата выпуска | 1995 |
| dc.description | Eleven patients with clinically definite MS and three healthy controls were investigated by magnetic resonance spectroscopic imaging. The data sets were analysed for all voxels containing white matter only. We classify these voxels in healthy controls as normal white matter (NWM), and in MS patients as normal-appearing white matter unaffected by MS lesions (NAWM) or white matter affected by MS lesions. The spectra belonging to the voxels were analysed for content of cholines, creatines and N-ocetylasportote (NAA), and compared as a group. It was found that lesions differ from white matter in chemical composition and, moreover, that normal-appearing white matter differs from healthy white matter. Specifically, levels of NAA are lower in patients. There seems to be a linear relation between the composition of white matter and the expanded disability status scale value for the patient The presence of lactate could not be established, and no unambiguous differences were found between patients with relapsing-remitting and relapsing-progressive disease. |
| Издатель | SAGE Publications |
| Тема | magnetic resonance imaging methods |
| Тема | multiple sclerosis metabolism |
| Тема | brain-pathology |
| Тема | brain-chemistry |
| Название | A study of multiple sclerosis patients with magnetic resonance spectroscopic imaging |
| Тип | Journal Article |
| DOI | 10.1177/135245859500100105 |
| Electronic ISSN | 1477-0970 |
| Print ISSN | 1352-4585 |
| Журнал | Multiple Sclerosis |
| Том | 1 |
| Первая страница | 25 |
| Последняя страница | 31 |
| Аффилиация | Peters, AR, Departments of Radiology, PO Box 50000, NL-7500 KA Enschede, The Netherlands |
| Аффилиация | Geelen, JAG, Neurology, Medisch Spectrum Twente, PO Box 50000, NL-7500 KA Enschede, The Netherlands |
| Аффилиация | denBoer, JA, Departments of Radiology, PO Box 50000, NL-7500 KA Enschede, The Netherlands |
| Аффилиация | Prevo, RL, Departments of Radiology, PO Box 50000, NL-7500 KA Enschede, The Netherlands |
| Аффилиация | Minderhoud, JM, Department of Neurology, University Hospital Groningen, PO Box 30001, NL-9700 RB Groningen, The Netherlands |
| Аффилиация | ʼs-Gravenmade, EJ, Department of Neurology, University Hospital Groningen, PO Box 30001, NL-9700 RB Groningen, The Netherlands |
| Выпуск | 1 |
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