| Автор | Canto, MC, Dal |
| Автор | Melvold, RW |
| Автор | Kim, BS |
| Дата выпуска | 1995 |
| dc.description | Theilerʼs murine encephalomyelitis virus (TMEV) produces a chronic disease in its natural host, the mouse, characterised by primary inflammatory demyelination of the spinal cord. This viral infection is considered a very good model for human MS because the pathogenesis of myelin injury is mediated through the host immune response. Susceptibility and/or resistance to the demyelinating disease depend on multiple genes both in and outside the major histocompatibility complex (MHC). The pathological lesions in animals with different degrees of susceptibility vary in both their severity and in their ability to become remyelinated. In general, animals with intermediate levels of susceptibility show the best potential for remyelination. Most crosses of susceptible animals with resistant strains carrying the H-2<sup>b</sup> haplotype are resistant with only a couple of exceptions. One such exception is the (SJL/J × C57L/J)Fl hybrid, which is susceptible to the disease. To study whether the resistant genotype of C57L/J mice could modify the phenotypic expression of pathological lesions characteristic of the highly susceptible SJL/J mouse, we performed a light microscopical and ultrastructural study of the spinal cord of both parental strains and their Flprogeny. We focused particularly on the relationship between severity of inflammation, and especially macrophage infiltration, and the subsequent remyelinating potential of lesions. The results show a dramatic difference between the ability to remyelinate lesions by infected SJL/J mice vs similarly infected (SJL/L × C57L/J)Fl hybrids, and suggest an important influence by resistant genes in modulating the phenotypic expression of disease, including the ability to stimulate oligodendroglia-mediated remyelination. |
| Издатель | SAGE Publications |
| Тема | Theilerʼs virus |
| Тема | demyelination |
| Тема | remyelination |
| Тема | oligodendrocytes |
| Название | A hybrid between a resistant and a susceptible strain of mouse alters the pattern of Theilerʼs murine encephalomyelitis virus-induced white matter disease and favors oligodendrocyte-mediated remyelination |
| Тип | Journal Article |
| DOI | 10.1177/135245859500100207 |
| Electronic ISSN | 1477-0970 |
| Print ISSN | 1352-4585 |
| Журнал | Multiple Sclerosis |
| Том | 1 |
| Первая страница | 95 |
| Последняя страница | 103 |
| Аффилиация | Canto, MC, Dal, Departments of Pathology (Neuropathology) |
| Аффилиация | Melvold, RW, Microbiology-Immunology, Northwestern University Medical School, Chicago Illinois 60611, USA |
| Аффилиация | Kim, BS, Microbiology-Immunology, Northwestern University Medical School, Chicago Illinois 60611, USA |
| Выпуск | 2 |
| Библиографическая ссылка | 1 Pevear DC, Calenoff M, Rozhon E, Lipton HL. (1987) Analysis of the complete nucleotide sequence of the Picornavirus Theilerʼs murine encephalomyelitis virus indicates that it is closely related to cardioviruses. J Virol 61: 1507–1516. |
| Библиографическая ссылка | 2 Lipton HL. (1975) Theilerʼs virus infection in mice: an unusual biphasic disease process leading to demyelination. Infect Immun 11: 1147–1155. |
| Библиографическая ссылка | 3 Lipton HL. (1980) Persistent Theilerʼs murine encephalomyelitis virus infection in mice depends on plaque size. J Gen Virol 46: 169–177. |
| Библиографическая ссылка | 4 Lipton HL et al. (1984) Theilerʼs virus antigen detected in mouse spinal cord 2 1/2 years after infection. Neurology 34: 1117–1119. |
| Библиографическая ссылка | 5 Theiler M. (1937) Spontaneous encephalomyelitis of mice, a new virus disease. J Exp Med 65: 705–719. |
| Библиографическая ссылка | 6 Dal Canto MC. (1990) Experimental models of virus-indicated demyelination. In: Cook SM, ed. Handbook of Multiple Sclerosis, New York: Marcel Dekker, pp 63–100. |
| Библиографическая ссылка | 7 Dal Canto MC, Lipton HL. (1975) Primary demyelination in Theilerʼs virus infection. Lab Invest 33: 626–637. |
| Библиографическая ссылка | 8 Lipton HL, Dal Canto MC. (1976) Theilerʼs virus-induced demyelination: prevention by immunosuppression. Science 192: 62–64. |
| Библиографическая ссылка | 9 Rodriguez M, Leibowitz J, David CS. (1986) Susceptibility to Theilerʼs virus-induced demyelination. Mapping of the gene within the H-2D region. J Exp Med 163: 620–631. |
| Библиографическая ссылка | 10 Roos RO et al. (1982) The effect of short-term and chronic immunosuppression on Theilerʼs virus demyelination. J Neuroimmunol 2: 223–234. |
| Библиографическая ссылка | 11 Blankenhorn EP, Stranford SA. (1992) Genetic factors in demyelinating diseases: genes that control demyelination due to experimental allergic encephalomyelitis (EAE) and Theilerʼs murine encephalomyelitis virus. Regional Immunol 4: 331–343. |
| Библиографическая ссылка | 12 Lipton HL, Dal Canto MC. (1979) Susceptibility of inbred mice to chronic central nervous system infection by Theilerʼs murine encephalomyelitis virus. Infect Immun 26: 369–374. |
| Библиографическая ссылка | 13 Lipton HL, Melvold RW. (1984) Genetic analysis of susceptibility to Theilerʼs virus-induced demyelinating disease in mice. J Immunol 132: 1821–1825. |
| Библиографическая ссылка | 14 Clatch RJ et al. (1985) Theilerʼs murine encephalo myelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TMEV-specific delayed-type hypersensitivity. J Immunol 135: 1408–1414. |
| Библиографическая ссылка | 15 Clatch RJ et al. (1987) The Theilerʼs murine encephalo-myelitis virus (TMEV) model for multiple sclerosis shows a strong influence of the murine equivalents of HLA-A, B and C. J Neuroimmunol 15: 121–135. |
| Библиографическая ссылка | 16 Melvold RW et al. (1987) H-2 genes in TMEV-induced demyelination, a model for multiple sclerosis. In: David C, ed. Major Histocompatibility Genes and their Role in Immune Function, New York: Plenum, pp 735–745. |
| Библиографическая ссылка | 17 Rodriguez M, David CS. (1985) Demyelination induced by Theilerʼs virus: Influence of the H-2 complex. J Immunol 135: 2145–2148. |
| Библиографическая ссылка | 18 Currier RD, Eldridge R. (1981) Possible risk factors in multiple sclerosis as found in a national twin study. Arch Neurol 39: 140–144. |
| Библиографическая ссылка | 19 Ebers GC et al. (1986) A population-based study of multiple sclerosis in twins. N Engl J Med 315: 1638–1642. |
| Библиографическая ссылка | 20 Engell T, Raun NE, Thomsen M, Platz P. (1982) HLA and heterogeneity of multiple sclerosis. Neurology 32: 1043–1046. |
| Библиографическая ссылка | 21 Oksenberg JR et al. (1989) T cell receptor Vα and Cα alleles associated with multiple sclerosis and myastenia gravis. Proc Natl Acad Sci USA 86: 988–992. |
| Библиографическая ссылка | 22 Patick AK, Pease LR, David CS, Rodriguez M. (1990) Major histocompatibility complex-conferred resistance to Theilerʼs virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice. J Virol 64: 5570–5576. |
| Библиографическая ссылка | 23 Sadovnick AD, Baird PA, Ward RH. (1988) Multiple sclerosis: updated risks for relatives. Am J Genet 29: 533–541. |
| Библиографическая ссылка | 24 Kurtzke J, Hyllested J. (1979) Multiple sclerosis in the Faroe Islands. I. Clinical and epidemiological features. Ann Neurol 5: 6–21. |
| Библиографическая ссылка | 25 Poser CM. (1993) The pathogenesis of multiple sclerosis. Additional considerations. J Neurol Sci 115 (suppl.) S3–S15. |
| Библиографическая ссылка | 26 Clatch RJ, Lipton HL, Miller SD. (1986) Characterization of Theilerʼs murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs. J Immunol 136: 920–927. |
| Библиографическая ссылка | 27 Clatch RJ, Lipton HL, Miller SD. (1987) Class II restricted T cell responses in Theilerʼs murine encephalomyelitis virus (TMEV)-induced demyelinating disease. II. Survey of host immune responses and central nervous system titers in inbred mouse strains. Microb Pathogen 3: 327–337. |
| Библиографическая ссылка | 28 Miller SD et al. (1987) Class II restricted T cell responses in Theilerʼs murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I Cross specificity among TMEV substrains and related picornaviruses, but not myelin proteins. J Immunol 138: 3776–3784. |
| Библиографическая ссылка | 29 Miller SD et al. (1990) Class II restricted T cell responses in Theilerʼs murine encephalomyelitis virus (TMEV)-induced demylinating disease. III. Failure of neuroantigen-specific immune tolerance to affect the clinical course of demyelination. J Neuroimmunol 26: 9–23. |
| Библиографическая ссылка | 30 Miller SD, Gerety SI. (1990) Immunologic aspects of Theilerʼs murine encephalomyelitis virus-induced demyelinating disease. Semin Virol 1: 263–272. |
| Библиографическая ссылка | 31 Dal Canto MC, Melvold RW, Kim BS, Miller SD. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theilerʼs murine encephalomyelitis virus (TMEV) infection — a pathological and immunological comparison. Micr Res Techn (in press). |
| Библиографическая ссылка | 32 Kappel CA, Melvold RW, Kim BS. (1990) Influence of sex on susceptibility in the Theilerʼs murine encephalomyelitis virus model for multiple sclerosis. J Neuroimmunol 29: 15–19. |
| Библиографическая ссылка | 33 Kappel CA, Dal Canto MC, Melvold RW, Kim BS. (1991) Hierarchy of effects of the major histocompatibility complex and the T cell receptor β-chain genes in susceptibility to Theilerʼs murine encephalomyelitis virus-induced demyelinating disease. J Immunol 147: 4322–4326. |
| Библиографическая ссылка | 34 Melvold RW, Jokinen DM, Knobler R, Lipton HL. (1987) Variations in genetic control of susceptibility to Theilerʼs murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Differences between susceptible SJL/J and resistant BALB/c strain map near the T cell beta chain constant genes on chromosome 6. J Immunol 138: 1429–1433. |
| Библиографическая ссылка | 35 Melvold RW et al. (1990) Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theilerʼs murine encephalomyelitis virus (TMEV)-induced demyelinating disease. J Virol 64: 686–690. |
| Библиографическая ссылка | 36 Bureau JF et al. (1992) The interaction of two groups of murine genes determines the persistence of Theilerʼs virus in the central nervous system. J Virol 66: 4698–4704. |
| Библиографическая ссылка | 37 Bureau JF et al. (1993) Genetic analysis of the persistence of Theilerʼs virus in the central nervous system of the mouse. Nature Genet 5: 87. |
| Библиографическая ссылка | 38 Nicholson SM et al. (1995) Genetic analysis of susceptibility to TMEV-induced demyelinating disease in the SWR strain. J Neuroimmunol (in press). |
| Библиографическая ссылка | 39 Prineas JW. (1990) Pathology of multiple sclerosis. In Handbook of Multiple Sclerosis, Cook, SD, ed. New York: Marcel Dekker, pp 187–218. |
| Библиографическая ссылка | 40 Raine CS. (1991) Multiple sclerosis: a pivotal role for the T cell in lesion development. Neuropathol Appl Neurobiol 17: 265–274. |
| Библиографическая ссылка | 41 Epstein LG, Prineas JW, Raine CS. (1983) Attachment of myelin to coated pits on macrophages in experimental allergic encephalomyelitis. J Neurol Sci 61: 341–348. |
| Библиографическая ссылка | 42 Raine CS, Scheinberg LC. (1988) On the immunopathology of plaque development and repair in multiple sclerosis. J Neuroimmunol 120: 180–201. |
| Библиографическая ссылка | 43 Dal Canto MC et al. (1975) Vesicular disruption of myelin in autoimmune demyelination. J Neurol Sci 24: 313–319. |
| Библиографическая ссылка | 44 Hof man FM, Hinton DR, Johnson K, Merrill JE. (1989) Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med 170: 607–612. |
| Библиографическая ссылка | 45 Selmaj K, Raine CS. (1988) Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 23: 339–346. |
| Библиографическая ссылка | 46 Prineas JW et al. (1993) Multiple Sclerosis. Pathology of recurrent lesions. Brain 116: 681–693. |
| Библиографическая ссылка | 47 Rodriguez M, Lennon V, Benveniste E, Merrill JE. (1987) Remyelination by oligodendrocytes stimulated by antiserum to spinal cord. J Neuropathol Exp. Neurol 40: 84–95. |
| Библиографическая ссылка | 48 Rodriguez M, Pierce M, Thiemann RL. (1991) Immunoglobulins stimulate central nervous system remyelination: electron microscopic and morphometric analysis of proliferating cells. Lab Invest 64: 358–370. |
| Библиографическая ссылка | 49 Rodriguez M, Lindsley M. (1992) Immunosuppression promotes central nervous system remyelination in chronic virus-induced demyelinating disease. Neurology 42: 348–357. |
