| Автор | Sandberg-Wollheim, M |
| Автор | Ciusani, E |
| Автор | Salmaggi, A |
| Автор | Pociot, F |
| Дата выпуска | 1995 |
| dc.description | We have analyzed the distribution of tumor necrosis factor (TNF) a and-b microsatellite alleles in HLA-DQ and-DR typed Swedish patients with multiple sclerosis (MS) (n=l22) and ethnically matched control subjects (n=l78). We found significant differences in the frequencies of TNFa and TNFb alleles between patients and controls. TNFal I was significantly associated with MS. This was also the case for the combination of TNFal I with TNFb4. However, TNFal I (alone or in combination with TNFb4) did not show any disease association independent of DQA 1*01021 DQBI*0602/DR2, whereas the previously reported strong association with HLA-DQAI*0102/DQBI*0602/DR2 in Scandinavian populations was confirmed. Therefore the association of TNFal I (and TNFb4) is most likely secondary to the increase of DQAI*0102/DQBl*0602/DR2 in MS patients. The proportion of TNFa6 positive individuals was lower among DR2-negative MS patients than among DR2-negative controls (p=0.08). Since the presence of the TNFab allele correlates with low TNFα production in response to lipopolysaccharide, it could be speculated that DR2-negative MS patients have an increased risk of being high TNFα producers in response to exogenous stimuli. |
| Издатель | SAGE Publications |
| Тема | TNFα |
| Тема | microsatellites |
| Тема | MS |
| Тема | HLA |
| Тема | genetics |
| Название | An evaluation of tumor necrosis factor microsatellite alleles in genetic susceptibility to multiple sclerosis |
| Тип | Journal Article |
| DOI | 10.1177/135245859500100309 |
| Electronic ISSN | 1477-0970 |
| Print ISSN | 1352-4585 |
| Журнал | Multiple Sclerosis |
| Том | 1 |
| Первая страница | 181 |
| Последняя страница | 185 |
| Аффилиация | Sandberg-Wollheim, M, Department of Neurology, Lund University Hospital, S-221 85 Lund, Sweden |
| Аффилиация | Ciusani, E, Department of Neurology, Lund University Hospital, S-221 85 Lund, Sweden |
| Аффилиация | Salmaggi, A, Istituto Nazionale Neurologico ‘C. BestaʼI-20 133 Milano, Italy |
| Аффилиация | Pociot, F, Steno Diabetes Center, DK-2820 Gentof te, Denmark |
| Выпуск | 3 |
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