| Автор | Zhang, Jingwu |
| Автор | Raus, Jef |
| Дата выпуска | 1996 |
| dc.description | T cell responses to myelin bask protein (MBP) are implicated to play an important role in the pathogenesis of multiple sclerosis (MS). These MBP autoreactive T cells are found to undergo in vivo activation and clonal expansion in patients with MS. They accumulate in the brain compartment and may reside in the brain lesions of patients with MS. As MBP-reactive T cells potentially hold a central position in initiation and perpetuation of the brain inflammation, specific immune therapies designed to deplete them may improve the clinical course of the disease. In this paper, the therapeutic potential of T cell vaccination in the treatment of MS is discussed in context of its immunological and clinical effect The results of our phase one clinical vial indicate that T cell vaccination with inactivated MBP autoreactive T cells induces specific regulatory T cell network of the host immune system to deplete circulating MBP-reactive T cells in a clonotype-specific fashion. The immunity induced by T cell vaccination is clonotype-specific and long-lasting. Our longitudinal clinical evaluation further suggests a moderate reduction of rate of clinical exacerbation, disability score and the brain lesions (measured by magnetic resonance imaging) in vaccinated patients, as compared to matched controls. Our study should encourage further investigation on the treatment efficacy of T cell vaccination and further improvement for its clinical application. |
| Издатель | SAGE Publications |
| Тема | multiple sclerosis |
| Тема | autoimmunity |
| Тема | immunotherapy |
| Тема | autoreactive T-cells |
| Тема | T-cell vaccination |
| Название | T cell vaccination in multiple sclerosis |
| Тип | Journal Article |
| DOI | 10.1177/135245859600100615 |
| Electronic ISSN | 1477-0970 |
| Print ISSN | 1352-4585 |
| Журнал | Multiple Sclerosis |
| Том | 1 |
| Первая страница | 353 |
| Последняя страница | 356 |
| Аффилиация | Zhang, Jingwu, Dr L Willems Instituut and Limburgs Universitair Centrum, Diepenbeek, Belgium |
| Аффилиация | Raus, Jef, Dr L Willems Instituut and Limburgs Universitair Centrum, Diepenbeek, Belgium |
| Выпуск | 6 |
| Библиографическая ссылка | 1 Zhang J. (1995) Multiple sclerosis: Perspectives on autoimmune pathology and prospects for therapy. In: Appel S. ed. Current Neurology. 15th vol. Chicago: Mosby-Year Book, pp 115–155. |
| Библиографическая ссылка | 2 Ben-Nun A, Cohen IR. (1982) Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells. J Immunol 129: 303–309. |
| Библиографическая ссылка | 3 Vandenbark AA et al. (1985) Specificity of T cell lines for peptides of myelin basic protein. J Immunol 135: 135–229. |
| Библиографическая ссылка | 4 Mor F, Cohen IR. (1993) Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis. J Clin Invest 92: 2199–2206. |
| Библиографическая ссылка | 5 Ben-Nun A, Wekerle H, Cohen IR. (1981) Vaccination against autoimmune encephalomyelitis with T lymphocyte line cells reactive against myelin basic protein. Nature 292: 60–61. |
| Библиографическая ссылка | 6 Vandenbark AA, Hashim GA, offner H. (1989) Immunization with a synthetic T cell receptor V region peptide protects against experimental autoimmune encephalomyelitis. Nature 341: 541–544. |
| Библиографическая ссылка | 7 Acha-Orbea H et al. (1988) Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54: 263–273. |
| Библиографическая ссылка | 8 Zhang JW et al. (1994) Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 179: 973–984. |
| Библиографическая ссылка | 9 Chou YK et al. (1992) Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J Neuroimmunol 38: 105–114. |
| Библиографическая ссылка | 10 Allegretta M et al. (1990) T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 247: 718–721. |
| Библиографическая ссылка | 11 Oksenberg J et al. (1993) Selection for T cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362: 68–73. |
| Библиографическая ссылка | 12 Vandevyver C et al. (1995) Clonal expansion of myelin basic protein-reactive T cells in patients with multiple sclerosis: restricted T cell receptor V gene rearrangements and CDR3 sequence. Eur J Immunol 25: 958–968. |
| Библиографическая ссылка | 13 Wucherpfennig KW et al. (1994) Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J Immunol 152: 5581–5592. |
| Библиографическая ссылка | 14 Hohlfeld R et al. (1995) The role of autoimmune T lymphocytes in the pathogenesis of multiple sclerosis. Neurology 45: 533–538. |
| Библиографическая ссылка | 15 Lider O et al. (1988) Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science 239: 181–184. |
| Библиографическая ссылка | 16 Lohse AW et al. (1989) Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells. Science 244: 820–822. |
| Библиографическая ссылка | 17 Davis MM, Bjorkman PJ. (1988) T cell antigen receptor genes and T cell recognition. Nature 334: 393–402. |
| Библиографическая ссылка | 18 Saruham-Direskeneli G et al. (1993) Human T cell autoimmunity against myelin basic protein: CD4+ cells recognizing epitopes of the T cell receptor β chain from a myelin basic protein-specific T cell clone. Eur J Immunol 23: 530–540. |
| Библиографическая ссылка | 19 Zhang J, Raus J. (1995) T cell vaccination trial in multiple sclerosis. In: Zhang J, Raus J. eds. Autoimmune disease and T cell vaccination. Austin: Springer-Verlag, Landes Medical Publishers pp 135–160. |
| Библиографическая ссылка | 20 Zhang J, Raus J. (1993) T cell vaccination in human autoimmune diseases: from laboratory to clinic. Hum Immunol (editorial) 38: 87–96. |
| Библиографическая ссылка | 21 Zhang J et al. (1993) MHC restricted clonotypic depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 261: 1451–1454. |
| Библиографическая ссылка | 22 Medaer R, Stinissen P, Raus J, Zhang J. (1995) Depletion of myelin basic protein autoreactive T cells by T cell vaccination: Clinical trial in multiple sclerosis. Lancet 346: 807–808. |
| Библиографическая ссылка | 23 Zhang J, Vandevyver C, Stinissen P, Raus J. (1995) In vivo clonotypic regulation of human myelin basic protein-reactive T cells by T cell vaccination. J Immunol 155: 5868–5877. |
