| Автор | Lindsey, JW |
| Автор | Kerman, RH |
| Автор | Wolinsky, JS |
| Дата выпуска | 1997 |
| dc.description | Activated T cells are able to stimulate proliferation in resting T cells through an antigen non-specific mechanism. The in vivo usefulness of this T cell-T cell activation is unclear, but it may serve to amplify immune responses. T cell-T cell activation could be involved in the well-documented occurrence of multiple sclerosis (MS) exacerbations following viral infections. Excessive activation via this pathway could also be a factor in the etiology of MS. We tested the hypothesis that excessive T cell-T cell activation occurs in MS patients using in vitro proliferation assays comparing T cells from MS patients to T cells from controls. When tested as responder cells, T cells from MS patients proliferated slightly less after stimulation with previously activated cells than T cells from controls. When tested as stimulator cells, activated cells from MS patients stimulated slightly more non-specific proliferation than activated cells from controls. Neither of these differences were statistically significant We conclude that T cell proliferation in response to activated T cells is similar in MS and controls. |
| Издатель | Sage Publications |
| Тема | multiple sclerosis |
| Тема | T-lymphocytes |
| Тема | proliferation |
| Название | T cell-T cell activation in multiple sclerosis |
| Тип | Journal Article |
| DOI | 10.1177/135245859700300404 |
| Print ISSN | 1352-4585 |
| Журнал | Multiple Sclerosis |
| Том | 3 |
| Первая страница | 238 |
| Последняя страница | 242 |
| Аффилиация | Lindsey, JW, Department of Neurology, University of Texas-Houston Medical School, Houston, Texas 77030, USA |
| Аффилиация | Kerman, RH, Department of Surgery, University of Texas-Houston Medical School, Houston, Texas 77030, USA |
| Аффилиация | Wolinsky, JS, Department of Neurology, University of Texas-Houston Medical School, Houston, Texas 77030, USA |
| Выпуск | 4 |
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