| Автор | Sacks, Gordon |
| Дата выпуска | 1997 |
| dc.description | Plasma concentrations of the antioxidant vitamin ascorbic acid were measured by high-performance liquid chromatography in critically ill patients in whom the excessive generation of reactive oxygen species could compromise antioxidant defense mechanisms. Median concentrations of both total vitamin C (ascorbic acid and dehydroascorbic acid) and ascorbic acid in these patients were > 25% (p > 0.001) of the values found in healthy control subjects and in subjects in two other disease groups (diabetes, gastritis) in which reactive oxygen species are reported to be increased. The low values could not be explained by age, sex, intake, or treatment differences, but were associated with the severity of the illness and were not prevented by the use of parenteral nutrition containing ascorbic acid. In addition, the vitamin was less stable in blood samples taken from critically ill patients than in similar samples from subjects in other groups. The findings indicate that antioxidant defenses could be considerably compromised in these very sick patients. If this reduces the patientʼs capacity to scavenge reactive species, then the potential of these species to damage DNA and lipid membranes could be increased and compromise recovery. (Am J Clin Nutr 1996;63:760–5) |
| Издатель | SAGE Publications |
| Название | Total Vitamin C, Ascorbic Acid, and Dehydroascorbic Acid Concentrations in Plasma of Critically Ill Patients |
| Тип | Journal Article |
| DOI | 10.1177/088453369701200111 |
| Electronic ISSN | 1941-2452 |
| Print ISSN | 0884-5336 |
| Журнал | Nutrition in Clinical Practice |
| Том | 12 |
| Первая страница | 43 |
| Последняя страница | 43 |
| Выпуск | 1 |
| Библиографическая ссылка | 1. Irwin MI, Hutchins BK. A comspectus of research on vitamin C requirements of man. J Nutr 1976;106:823–79. |
| Библиографическая ссылка | 2. Brook M, Grinshaw JJ. Vitamin C concentrations of plasma and leukocytes as related to smoking habit, age, and sex of humans. Am J Clin Nutr 1968;21:1254–8. |
