| Автор | Wright, Robert, B. |
| Автор | Costa, Jonathan, L. |
| Автор | Brandabur, Melanie |
| Автор | Junger, Sylvain |
| Автор | McRae, Amanda |
| Автор | Carvey, Paul, M. |
| Дата выпуска | 1990 |
| dc.description | A patient with a variant of akinetic mutism had responded to Sinemet and had been maintained at a functional level on this medication. We report follow-up studies of his speech and language skills, blink rate, and cerebrospinal fluid amine metabolites while on Sinemet and following its withdrawal. On Sinemet, cerebrospinal dopamine metabolites were normal at 90 min postdose. Off Sinemet, the patient experienced no clinical deterioration and some improvement in his speech and language skills. Although the cerebrospinal dopamine metabolites fell to markedly subnormal levels, his blink rate remained abnormally high (85–100/min) for 5 weeks. An antibody to dopaminergic neurons was present in the cerebrospinal fluid. The data suggest that the patient had sustained damage to the substantia nigra, with a resultant deficit in endogenous dopamine production. Remodeling appears to have occurred in the striatal system despite Sinemet-induced normal levels of dopamine available for release by striatal neurons. |
| Издатель | SAGE Publications |
| Тема | Akinetic mutism |
| Тема | Parkinsonʼs disease |
| Тема | Sinemet |
| Тема | Dopamine |
| Тема | Cerebrospinal fluid amine metabolites |
| Название | A Variant of Akinetic Mutism: Biochemical and Physiological Studies During Successful Withdrawal from Sinemet |
| Тип | Journal Article |
| DOI | 10.1177/088843909000400307 |
| Print ISSN | 0888-4390 |
| Журнал | Journal of Neurologic Rehabilitation |
| Том | 4 |
| Первая страница | 163 |
| Последняя страница | 167 |
| Аффилиация | Wright, Robert, B., Departments of Neurological Sciences |
| Аффилиация | Costa, Jonathan, L., Physical Medicine and Rehabilitation, Rush-Presbyterian-St. Lukeʼs Medical Center, Chicago, IL, U.S.A. |
| Аффилиация | Brandabur, Melanie, Departments of Neurological Sciences |
| Аффилиация | Junger, Sylvain, Departments of Neurological Sciences |
| Аффилиация | McRae, Amanda, Neuroscience Research Center of Goteborg, Institute of Neurobiology, Goteborg, Sweden. |
| Аффилиация | Carvey, Paul, M., Departments of Neurological Sciences |
| Выпуск | 3 |
| Библиографическая ссылка | 1. Plum F, Posner JB. The diagnosis of stupor and coma. Philadelphia: FA Davis, 1966. |
| Библиографическая ссылка | 2. Karp JS, Hurtig HI. “Locked-in” state with bilateral mid-brain infarcts. Arch Neurol 1974; 30: 176–8. |
| Библиографическая ссылка | 3. Barbieri F, Sinisi L, Cirillo S, Delehaje L, Mansi D. Long-term observation of two cases of locked-in syndrome with recovery. Gin Neurol Neurosurg 1987; 89(3): 177–80. |
| Библиографическая ссылка | 4. Cabezudo JM, Olabe J, Lopez-Anguera A, Bacci F. Recovery from locked-in syndrome after post-traumatic bilateral distal vertebral artery occlusion. Surg Neurol 1986; 25: 185–90. |
| Библиографическая ссылка | 5. Sulkava R, Kovanen J. Locked-in syndrome with rapid recovery: a manifestation of basilar artery migraine? Headache 1983; 23: 238–9. |
| Библиографическая ссылка | 6. Hall JH, Karp HR. Acute progressive ventral pontine disease in heroin abuse. Neurology 1973; 23: 6–7. |
| Библиографическая ссылка | 7. Nemeth G, Hegedus K, Molnar L. Akinetic mutism and locked-in syndrome: the functional-anatomical basis for their differentiation. Funct Neurol 1986; 1: 128–39. |
| Библиографическая ссылка | 8. Ross ED, Stewart RM. Akinetic mutism from hypothalamic damage: successful treatment with dopamine agonists. Neurology 1981; 31: 1435–9. |
| Библиографическая ссылка | 9. Tanji H, Takahashi M, Masu K, et al. Intrathecal administration of CDP-choline into the lower lumbar subarachnoid space in two patients with post-traumatic akinetic mutism. Fukushima J Med Sci 1976; 22: 31–47. |
| Библиографическая ссылка | 10. McGuire TJ, Hodges DL, Medhat MA, Redford JB. Transient locked-in syndrome and phenobarbital. Arch Phys Med Rehabil 1987; 68: 566–7. |
| Библиографическая ссылка | 11. Forti A, Ambrosetto G, Amore M, et al. Locked-in syndrome in multiple sclerosis with sparing of the ventral portion of the pons. Arch Neurol 1982; 12: 393–94. |
| Библиографическая ссылка | 12. Rao N, Costa JL. Recovery in non-vascular locked-in syndrome during treatment with Sinemet. Brain Injury 1989; 3: 207–11. |
| Библиографическая ссылка | 13. Granger ME. Exacerbations in parkinsonism. Neurology 1961; 11: 538–45. |
| Библиографическая ссылка | 14. Grotjahn M. Klinik und Bedeutung akinetischer Zustande nach Luftfullung des dritten Ventrikels. Psychiatr Neurol 1936; 93: 121–39. |
| Библиографическая ссылка | 15. Cairns H, Oldfield RC, Pennybacker JB, Whitteridge D. Akinetic mutism with an epidermoid cyst of the 3rd ventricle. Brain 1941; 64: 273–90. |
| Библиографическая ссылка | 16. Karson CN, Burns S, LeWitt PA, Foster NL, Newman RP. Blink rates and disorders of movement. Neurology 1984; 34: 677–8. |
| Библиографическая ссылка | 17. Goetz CG, Tanner CM, Shannon KM, Carroll VS, Klawans HL, Carvey PM, Gilley D. Controlled-release carbidopa/levodopa (CR-4 Sinemet) in Parkinsonʼs disease patients with and without motor fluctuations. Neurology 1988; 38: 1143–6. |
| Библиографическая ссылка | 18. Carvey PM, Hitri A, Goetz CG, Tanner CM, Klawans HL. Concurrent treatment with benztropine and haloperidol attenuates the development of behavioral hypersensitivity but not DA receptor proliferation. Life Sci 1988; 42: 2207–15. |
| Библиографическая ссылка | 19. McRae-Degreurce A, Klawans HL, Penn RD, Dahlstrom A, Tanner CM, Goetz CG, Carvey PM. An antibody in the CSF of Parkinsonʼs disease patients disappears following adrenal medulla transplantation. Neurosci Lett 1988; 94: 192–7. |
| Библиографическая ссылка | 20. Harvey RF, Jellinek HM. Functional performance assessment: a program approach. Arch Phys Med Rehabil 1981; 68: 24–7. |
| Библиографическая ссылка | 21. Carvey PM, Klawans HL, Kao LC, Dahlstrom A, McRae A. An antibody in the CSF of Parkinsonʼs disease patients: summary of data and potential role as a diagnostic marker. N Vistas Drug Res 1990; 1: 31–40. |
| Библиографическая ссылка | 22. Nutt JG. Parkinsonʼs disease: evaluation and therapeutic strategy. Hosp Pract 1987; 22: 107–14. |
| Библиографическая ссылка | 23. Chase TN, Gordon EK, Ng LKJ. Norepinephrine metabolism in the central nervous system of man: studies using 3-methoxy-4-hydroxphenylethylene glycol levels in cerebrospinal fluid. J Neurochem 1973; 21: 581–7. |
| Библиографическая ссылка | 24. Calne DB, Langston JW. An etiology of Parkinsonʼs disease. Lancet 1983; 2: 1457–9. |
