| Автор | Schwab, Manfred |
| Автор | Corvi, Raffaella |
| Автор | Amler, Lukas, C. |
| Дата выпуска | 1995 |
| dc.description | Increase of the dosage of cellular oncogenes by DNA amplification is a frequent genetic alteration of cancer cells and arises as the consequence of genomic instability. The presence of amplified cellular oncogenes is usually signaled by conspicuous chromosomal abnormalities "double minutes," or "homogeneously staining chromosomal regions." Some human cancers carry a specific amplified oncogene at high incidence. In neuroblastomas, which are tumors of the peripheral nervous system that arise from primitive neuroectodermal cells derived from neural crest, the amplification of the gene N-MYC has been associated with aggressively growing cancers and is an indicator for poor prognosis. N-MYC amplification is of predictive value for iden tifying neuroblastoma patients who either require specific therapeutic regimens or who do not benefit from chemotherapy. The Neuroscientist 1:277-285, 1995 |
| Издатель | Sage Publications |
| Тема | KEY WORDS N-MYC |
| Тема | p53 |
| Тема | Tumorigenesis |
| Тема | Neuroblastoma |
| Тема | Gene amplification |
| Тема | Oncogenes |
| Название | N-MYC Oncogene Amplification: A Consequence of Genomic Instability in Human Neuroblastoma |
| Тип | Journal Article |
| DOI | 10.1177/107385849500100505 |
| Print ISSN | 1073-8584 |
| Журнал | The Neuroscientist |
| Том | 1 |
| Первая страница | 277 |
| Последняя страница | 285 |
| Аффилиация | Schwab, Manfred, German Cancer Research Center Division of Cytogenetics Heidelberg, Germany |
| Аффилиация | Corvi, Raffaella, German Cancer Research Center Division of Cytogenetics Heidelberg, Germany |
| Аффилиация | Amler, Lukas, C., German Cancer Research Center Division of Cytogenetics Heidelberg, Germany |
| Выпуск | 5 |
| Библиографическая ссылка | Kramer S., Meadows AT, Jarrett P., Evans AEIncidence of childhood cancer: experience of a decade in a population-based registry. J Natl Cancer Inst1983;70:49. |
| Библиографическая ссылка | Michaelis J. , Kaatsch P. Cooperative documentation of childhood malignancies in the FRG. System design and five-year results. Monogr Paediatr 1986;18:56-67. |
| Библиографическая ссылка | Beckwith JB, Pemn EVIn situ neuroblastomas: a contribution to the natural history of neural crest tumors. Am J Pathol1963;43:1089-1104. |
| Библиографическая ссылка | Hasegawa R., Tatematsu M., Imaida K.Neuroblastoma in situ. Acta Pathol Jpn1982 ;32:537-541. |
| Библиографическая ссылка | Evans AE, D'Angio GB, Randolph J.A proposed staging for children with neuroblastoma. Cancer1971;27:374-378. |
| Библиографическая ссылка | Brodeur GM, Pntchard J., Berthold F., et al. Revisions of the international criteria for neuroblastoma diagnosis, staging and response to treatment. J Clin Oncol1993; 11:1466-1477. |
| Библиографическая ссылка | Berthold F.Overview: biology of neuroblastoma. In: Pochedly C, editor. Neuroblastoma: tumor biology and therapy. Boca Raton, FL: CRC Press Inc1990 :1-27. |
| Библиографическая ссылка | Kushner BH, Gilbert F., Helson L.Familial neuroblastoma: case reports, literature review, and etiologic considerations . Cancer 1986;57:1887-1893. |
| Библиографическая ссылка | Schwab M, Pearson ADJ, editors. Advances in clinic and biology of neuroblastoma. Eur J Cancer 1995;31A. |
| Библиографическая ссылка | Alitalo K., Schwab M.Oncogene amplification in tumor cells. Adv Cancer Res1986;47:235-281. |
| Библиографическая ссылка | Kallioniemi A., Kallioniemi O-P, Sudar D., et al. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science1992;258:818-821. |
| Библиографическая ссылка | Schwab M., Amler LCAmplification of cellular oncogenes: a predictor of clinical outcome in human cancer. Genes Chromosom Cancer1990;1:181-193. |
| Библиографическая ссылка | Schimke RTGene amplification in cultured animal cells. Cell1984;37:705-713. |
| Библиографическая ссылка | Windle B., Draper BW, Yin Y., O'Gorman S., Wahl GMA central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes Dev1991;5:160-174. |
| Библиографическая ссылка | Stark GRRegulation and mechanisms of mammalian gene amplification. Adv Cancer Res1993;61:87-113. |
| Библиографическая ссылка | Schwab M., Alitalo K., Klempnauer KH, et al. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumor. Nature1983;305:245-248. |
| Библиографическая ссылка | Fuller G., Bigner S.Amplified cellular oncogenes in neoplasms of the central nervous system. Mutat Res1992;276:299-306. |
| Библиографическая ссылка | Lee WH, Murphree AL, Benedict WFExpression and amplification of the MYCN gene in primary retinoblastoma. Nature1984;309:458-460. |
| Библиографическая ссылка | Garson JA, McIntyre PG, Kemshead JTMYCN amplification in malignant astrocytoma. Lancet1985;8457:718-719. |
| Библиографическая ссылка | Nau M., Brooks B., Carney D., et al. Human small-cell lung cancers show amplification and expression of the MYCN gene. Proc Natl Acad Sci U S A1986;83:1092-1096. |
| Библиографическая ссылка | Schwab M., Varmus HE, Bishop JMHuman N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature1985;316:160-162. |
| Библиографическая ссылка | Small MB, Hay N., Schwab M., Bishop JMNeoplastic transformation by the human gene MYCN. Mol Cell Biol1987;1638-1645. |
| Библиографическая ссылка | Schweigerer L., Breit S., Wenzel A., Tsunamoto K., Ludwig R., Schwab M.Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity. Cancer Res1990;50: 4411-4416. |
| Библиографическая ссылка | Schwab M., Bishop JMSustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence. Proc Natl Acad Sci U S A1988;85:9585-9589. |
| Библиографическая ссылка | van Lohuizen M., Breuer M., Berns A.N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas. EMBO J1989;8:133-136. |
| Библиографическая ссылка | Dildrop R., Ma A., Zimmermann K., et al. IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasisas that lack c-myc expression . EMBO J 1989;8:1121-1128. |
| Библиографическая ссылка | Rosenbaum H. , Webb E., Adams JM, Cory S., Harris AW N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc. EMBO J 1989;8:749-755. |
| Библиографическая ссылка | Stanton BR, Perkins AS, Tessarolo L., Sassoon DA, Parada LFLoss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev1992;6:2235-2247. |
| Библиографическая ссылка | Cheng JM, Hiemstra JL, Schneider SS, et al. Preferential amplification of the paternal allele of the MYCN gene in human neuroblastomas. Nat Genet1993 ;4:191-194. |
| Библиографическая ссылка | Schwab M., Varmus HE, Bishop JM, et al. Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc. Nature1984;308:288-291. |
| Библиографическая ссылка | Amler LC, Shibasaki Y., Savelyeva L., Schwab M.Amplification of the MYCN gene in human neuroblastomas: tandemly repeated amplicons within homogeneously staining regions on different chromosomes with the retention of single copy gene at the resident site. Mutat Res1992;276:291-297. |
| Библиографическая ссылка | Corvi R., Amler LC, Savelyeva L., Gehring M., Schwab M.MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells. Proc Natl Acad Sci U S A1994;91:5523-5527. |
| Библиографическая ссылка | Amler LC, Schwab M.Amplified MYCN in human neuroblastoma cells is often arranged as clustered tandem repeats of differently recombined DNA. Mol Cell Biol1989;9:4903-4913. |
| Библиографическая ссылка | Amler LC, Schwab M.Multiple amplicons of discrete sizes encompassing MYCN in neuroblastoma cells evolve through differential recombination from a large precursor DNA. Oncogene1992;7:807-809. |
| Библиографическая ссылка | Corvi R., Savelyeva L., Breit S., et al. Non-syntenic amplification of MDM2 and MYCN in human neuroblastomas . Oncogene 1995; 10:1081-1086. |
| Библиографическая ссылка | Hollstein M. , Sidransky D., Vogelstein B., Harris CC p53 mutations in human cancers. Science 1991;253:49-53. |
| Библиографическая ссылка | Ohgaki H., Eibl RH, Schwab M., et al. Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog1993;8:74-80. |
| Библиографическая ссылка | Gaudray P., Szeptowski P., Escot C., Birnbaum D., Theillet C.DNA amplification at 11q13 in human cancer: from complexity to perplexity . Mutat Res 1992;276:317-328. |
| Библиографическая ссылка | Squire JA, Thorner PS, Weitzman S., et al. Co-amplification of MYCN and a dead box gene (DDX1) in primary neuroblastoma. Oncogene1995; 10:1417-1422. |
| Библиографическая ссылка | Fong CT, Dracopoli NC, White PS, et al. Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with MYCN amplification. Proc Natl Acad Sci U S A1989;86:3753-3757. |
| Библиографическая ссылка | Caron H., van Sluis P., van Hoeve M., et al. Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with MYCN amplification. Nat Genet1993;4: 187-190. |
| Библиографическая ссылка | Martinsson T., Weith A., Cziepluch C., Schwab M.Chromosome 1 deletions in human neuroblastomas: generation and fine mapping of microclones from the distal 1p region. Genes Chromosom Cancer1989;1:67-78. |
| Библиографическая ссылка | Weith A., Martinsson T., Cziepluch C., et al. Neuroblastoma consensus deletion maps to chromosome 1p36.1-2 . Genes Chromosom Cancer 1989;1:159-166. |
| Библиографическая ссылка | Barker PE, Savelyeva L., Schwab M.Translocation junctions cluster at the distal short arm of chromosome 1 (1p36.1-2) in human neuroblastoma cells. Oncogene1993 ;8:3353-3358. |
| Библиографическая ссылка | Savelyeva L. , Corvi R., Schwab M. Translocation involving 1p and 17q is a recurrent genetic alteration of human neuroblastoma cells. Am J Hum Gent 1994;55:334-340. |
| Библиографическая ссылка | Takayama H. , Suzuki T., Mugishima H., et al. Deletion mapping of chromosomes 14q and 1p in human neuroblastoma. Oncogene 1992 ;7:1185-1189. |
| Библиографическая ссылка | Caron H., van Sluis P., van Roy N., et al. Recurrent 1;17 translocations in human neuroblastoma reveal nonhomologous mitotic recombination during the S/G2 phase as a novel mechanism for loss of heterozygosity. Am J Hum Genet1994;55: 341-347. |
| Библиографическая ссылка | Amler LC, Corvi R., Praml C., Savelyeva L., Le Paslier D., Schwab M.A reciprocal translocation (1;15)(36.2;q24) in a neuroblastoma cell line is accompanied by DNA duplication and may signal the site of a putative tumor suppressor-gene. Oncogene1995; 10:1095-1101. |
| Библиографическая ссылка | Schwab M.Is there a neuroblastoma anti-oncogene? In: Evans AE, D'Angio G, Knudson A, Seeger RC, editors. Advances in Neuroblastoma Research. New York: Wiley Liss1991; 3:1-9. |
| Библиографическая ссылка | Takeda O., Homma C., Maseki N., et al. There may be two tumor suppressor genes on chromosome arm 1p closely associated with biologically distinct subtypes of neuroblastoma. Genes Chromosom Cancer1994;10:30-39. |
| Библиографическая ссылка | Schleiermacher G., Peter M., Michon J., et al. Two distinct deleted regions on the short arm of chromosome 1 in neuroblastoma. Gene Chromosom Cancer1994;10:275-281. |
| Библиографическая ссылка | Laureys G., Speleman F., Opdenakker G., Benoit Y., Leroy J.Constitutional translocation t(1;17)(p36;q12-21) in a patient with neuroblastoma . Genes Chromosom Cancer 1990;2:252-254. |
| Библиографическая ссылка | Biegel JA, White PS, Marshall HN, et al. Constitutional 1p36 deletion in a child with neuroblastoma. Am J Hum Genet1993;52:176-182. |
| Библиографическая ссылка | Breit S., Schwab M.Suppression of MYC by high expression of NMYC in human neuroblastoma cells . J Neurosci Res 1989;24: 21-28. |
| Библиографическая ссылка | Schwab M., Ellison J., Busch M., Rosenau W., Varmus HE, Bishop JMEnhanced expression of the human gene MYCN consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. Proc Natl Acad Sci U S A1984;81:4940-4944. |
| Библиографическая ссылка | Kohl NE, Gee C., Alt F.Activated expression of the NMYC gene in human neuroblastomas and related tumors. Science1984;226: 1335-1338. |
| Библиографическая ссылка | Grady-Leopardi E., Schwab M., Ablin AR, Rosenau W.Detection of N-myc oncogene expression in human neuroblastoma by in situ hybridization and blot analysis: relationship to clinical outcome. Cancer Res1986;46:3196-3199. |
| Библиографическая ссылка | Grady E., Schwab M., Rosenau W.Expression of N-myc and c-src during the development of fetal human brain . Cancer Res 1987;47:2931-2936. |
| Библиографическая ссылка | Thiele CJ, Reynolds CP, Israel MADecreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma. Nature1985;313:404-406. |
| Библиографическая ссылка | Jakobovits A., Schwab M., Bishop JM, Martin GRExpression of N-myc in teratocarcinoma stem cells and mouse embryos. Nature1985;318:188-191. |
| Библиографическая ссылка | Thiele CJ, Israel MARegulation of N-myc expression is a critical event controlling the ability of human neuroblasts to differentiate. Exp Cell Biol1988;56:321-333. |
| Библиографическая ссылка | Hiller S., Breit S., Wang ZQ, Wagner EF, Schwab M.Localization of regulatory elements controlling human MYCN expression. Oncogene1991;6:969-977. |
| Библиографическая ссылка | Woodruff KA , Rosenblatt JD, Moore TB, et al. Cell type-specific activity of the N-myc promoter in human neuroblastoma cells is mediated by a downstream silencer . Oncogene 1995; 10:1335-1341. |
| Библиографическая ссылка | Stanton LW, Schwab M., Bishop JMNucleotide sequence of the human N-myc gene. Proc Natl Acad Sci U S A1986;83:1772-1776. |
| Библиографическая ссылка | Mäkelä TP, Saksela K., Alitalo K.Two MYCN polypeptides with distinct amino termini encoded by the second and third exons of the gene. Mol Cell Biol1989 ;9:1545-1552. |
| Библиографическая ссылка | Hamann U., Wenzel A., Frank R., Schwab M.The MYCN protein of human neuroblastoma cells is phosphorylated by casein kinase II in the central region and at serine 367. Oncogene1991;6:1745-1751. |
| Библиографическая ссылка | Schwab M.The MYC box oncogenes. In: Reddy EP, Skalka AM, Curran T, editors. The oncogene handbook. Elsevier Science Publishers BV1988:381-391. |
| Библиографическая ссылка | Wenzel A., Cziepluch C., Hamann U., Schürmann J., Schwab M.The MYCN oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells. EMBO J1991;10:3703-3712. |
| Библиографическая ссылка | Blackwood EM, Eisenman RNMax: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science1991;251:1211-1217. |
| Библиографическая ссылка | Mäkelä TP, Koskinen PJ, Västrik I., Alitalo K.Alternative forms of Max as enhancers of suppressors of myc-ras cotransformation . Science 1992;256:373-377. |
| Библиографическая ссылка | Ayer DE, Kretzner L., Eisenman RNMad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell1993;72:211-222. |
| Библиографическая ссылка | Kato GJ, Barrett J., Villa-Garcia M., Dang CVAn amino-terminal c-myc domain required for neoplastic transformation activities transcription. Mol Cell Biol1990;10:5914. |
| Библиографическая ссылка | Zervos AS, Gyuris J., Brent R.Mxil, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell1993;72:223-232. |
| Библиографическая ссылка | Cziepluch C. , 74. Cziepluch C., Wenzel A., Schürmann J., Schwab M. Activation of gene transcription by the amino terminus of the MYCN protein does not require association with the protein encoded by the retinoblastoma suppressor gene RB1. Oncogene 1993;8:2833-1838. |
| Библиографическая ссылка | Bartram CR, Berthold F.Amplification and expression of the MYCN gene in neuroblastoma. Eur J Pediatr1987;146:162-165. |
| Библиографическая ссылка | Brodeur G., Seeger RC, Schwab M., Varmus HE, Bishop JMAmplification of MYCN in untreated human neuroblastomas correlates with advanced disease stage. Science1984;224: 1121-1124. |
| Библиографическая ссылка | Seeger RC, Brodeur GM, Sather H., et al. Association of multiple copies of the MYCN oncogene with rapid progression of neuroblastomas. N Engl J Med1985;313:1111-1116. |
| Библиографическая ссылка | Nakagawara A., Ikeda K., Tsuda T., Higashi K.Biological characteristics of NMYC amplified neuroblastomas in patients over one year of age. Proc Clin Biol Res1988;271:31-39. |
| Библиографическая ссылка | Ambros PF, Ambros IM, Strehl S., et al. Regression and progression in neuroblastoma. Do genetics predict tumour behaviour? Eur J Cancer1995;31A:510-515. |
| Библиографическая ссылка | Taylor Cpf, McGuckin AG, Brown NP, et al. Rapid detection of prognostic genetic factors in neuroblastoma using fluorescence in situ hybridisation on tumour imprints and bone marrow smears. Br J Cancer1994;69:445-451. |
