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Автор Yuman Fong
Автор Moldawer, Lyle, L.
Автор Lowry, Stephen, F.
Дата выпуска 1992
dc.description Rapid advances in molecular biology have yielded important new techniques for understanding the cellular mechanisms of normal homeostasis and disease. In particular, molecular laboratory methodologies have become important investigative tools for nutritional studies. Detection techniques for specific DNAs, RNAs, and proteins allow direct examination of cellular regulation of protein expression in health and illness. Construction of transgeneic models by recent techniques of inserting foreign genes into experimental animals has provided novel models for studies of cellular metabolism. In addition, molecular biology has had impact on clinical nutrition and therapy. Molecular techniques not only allow for early diagnosis of many inborn genetic errors of metabolism, recombinant technology has also provided for large-scale production of proteins and hormones of potential therapeutic value. The possibility for direct gene therapies is also nearing reality. Hence, understanding the language of molecular biology and the recent developments in this field is not only of research interest, but is also of clinical relevance.(Journal of Parenteral and Enteral Nutrition 16:477-486, 1992)
Издатель Sage Publications
Название Review: Experimental and Clinical Applications of Molecular Cell Biology in Nutrition and Metabolism
Тип Reviews
DOI 10.1177/0148607192016005477
Print ISSN 0148-6071
Журнал Journal of Parenteral and Enteral Nutrition
Том 16
Первая страница 477
Последняя страница 486
Аффилиация Yuman Fong, Laboratory of Surgical Metabolism, Department of Surgery, New York Hospital-Cornell Medical Center, New York
Аффилиация Moldawer, Lyle, L., Laboratory of Surgical Metabolism, Department of Surgery, New York Hospital-Cornell Medical Center, New York
Аффилиация Lowry, Stephen, F., Laboratory of Surgical Metabolism, Department of Surgery, New York Hospital-Cornell Medical Center, New York
Выпуск 5
Библиографическая ссылка Mendel G.Versuche uber Pflanzen-Hybriden. Verh Naturforshung Ver Brunn4:3-47, 1765. Translated by Bateson WA, as Experiments in plant hybridization. IN Classic Papers in Genetics, Peters JA (ed). Prentice-Hall, New York , 1959
Библиографическая ссылка Avery OT, MacCleod M., McCarty M.: Studies in the chemical mature of the substance inducing transfer of pneumococcal types. J Exp Med79:137-158, 1944
Библиографическая ссылка Watson JD, Crick FHC: General implications of the structure of deoxyribonucleic acid. Nature171:964-967, 1953
Библиографическая ссылка Watson JD, Crick FHC: A structure for deoxyribose nucleic acid. Nature171:737-738, 1953
Библиографическая ссылка McKusick VA: Mapping and sequencing the human genome. N Engl J Med320:910-915, 1989
Библиографическая ссылка Congress of the United States Office of Technology Assessment Staff: Mapping Our Genes. Genome Projects: How Big, How Fast?The Johns Hopkins University Press, Baltimore, 1988
Библиографическая ссылка Fong Y., Lowry SF: Cytokines and the cellular response to injury and infection. IN Care of the Surgical Patient, Wilmore DW, Brennan MF, Harken AH , et al (eds). Scientific American, New York, 1990, IV:7:1-16
Библиографическая ссылка Fong Y., Moldawer LL, Marano M., et al: Endotoxemia elicits increased circulating β2-interferon/interleukin-6 in man. J Immunol142:2321-2325, 1989
Библиографическая ссылка Keogh C., Fong Y., Marano MA, et al: Identification of a novel tumor necrosis factor/cachectin from the livers of burned and infected rats. Arch Surg125:79-85, 1989
Библиографическая ссылка Munro HN, Fleck A.: Analysis for nitrogenous constituents. IN Mammalian Protein Metabolism, Vol III, Munro HN (ed). Academic Press, New York , 1969, pp 423-525
Библиографическая ссылка Millward DJ , Garlick PJ, James WPT, et al: Relationship between protein synthesis and RNA content in skeletal muscle. Nature 241:298-299, 1973
Библиографическая ссылка Fong Y., Moldawer LL, Marano MA, et al: Starvation leads to decreased levels of mRNA for myofibrillar proteins. J Surg Res46:457-461, 1989
Библиографическая ссылка Fong Y., Moldawer LL, Marano M., et al: Cachectin/TNF or IL-1α induces cachexia with redistribution of body proteins. Am J Physiol256:R659-R665, 1989
Библиографическая ссылка Fong Y., Minei JP, Marano MA, et al: Effects of thermal injury and infection on skeletal muscle membrane function, amino acid content, and mRNA for myofibrillar proteins. Am J Physiol261:R536-R542, 1991
Библиографическая ссылка Oppenheimer JH, Schwartz HL, Lane JT, et al: Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat. J Clin Invest87:125-132, 1991
Библиографическая ссылка Hill M., McCallum R.: Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment. J Clin Invest88:811-816, 1991
Библиографическая ссылка Popovich BK , Sayen MR, Dillmann WH: Insulin responsiveness of CK-M and CK-B mRNA in the diabetic rat heart. Am J Physiol 261:E377-E381, 1991
Библиографическая ссылка Dohm GL, Elton CW, Friedman JE, et al: Decreased expression of glucose transporter in muscle from insulin-resistant patients. Am J Physiol260:E459-E463, 1991
Библиографическая ссылка Marano M., Fong Y., Moldawer LL, et al: Infected burn injury alters hepatic monokine and albumin mRNA contents. Surg Forum39:6-7, 1988
Библиографическая ссылка Ulich TR, Guo K., del Castillo J.: Endotoxin-induced cytokine gene expression in vivo. Am J Pathol134:11-13, 1989
Библиографическая ссылка Boni-Schnetzler M., Schmid C., Meier PJ, Froesch ER: Insulin regulates insulin-like growth factor I mRNA in rat hepatocytes. Am J Physiol260:E846-E851, 1991
Библиографическая ссылка Gibbs RA: DNA amplification by the polymerase chain reaction. Anal Chem62:1202-1214, 1990
Библиографическая ссылка Veres G., Gibbs RA, Scherer SE, et al: The molecular basis of the sparse fur mouse mutation. Science237:415-417, 1987
Библиографическая ссылка Gibbs RA, Nguyen PN, Mcbride LJ, et al: Identification of mutations leading to the Lesch-Nyhan syndrome by automated direct DNA sequencing of in vitro amplified cDNA. Proc Natl Acad Sci USA89:1919-1923, 1989
Библиографическая ссылка Erlich H (ed): The Polymerase Chain Reaction: Principles and Application, Stockton Press , New York, 1989
Библиографическая ссылка Gershenwald JE, Fong Y., Fahey III TJ, et al: Interleukin-1 receptor blockade attenuates the host inflammatory response. Proc Natl Acad Sci USA87:4966-4970, 1990
Библиографическая ссылка Rappolee DA , Mark D., Banda MJ, et al: Wound macrophages express TGF-alpha and other growth factors in vivo: Analysis by mRNA phenotyping. Science 241:708-712, 1988
Библиографическая ссылка White JD, LaGamma EF: Neuropeptide gene transcription in central and peripheral nervous system tissue by nuclear run-on assay. Methods Enzymol168:681-690, 1989
Библиографическая ссылка Varmus H.: Retroviruses. Science240:1427-1435, 1988
Библиографическая ссылка Dzierzak EA , Papayannopoulou T., Mulligan RC Lineage-specific expression of a human beta-globin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells. Nature 331:35-41, 1988
Библиографическая ссылка Zwiebel JA, Freeman SM, Kantoff PW, et al: High-level recombinant gene expression in rabbit endothelial cells transduced by retroviral vectors. Science243:220- 243, 1988
Библиографическая ссылка Mann R., Mulligan RC, Baltimore D.Construction of a retrovirus packaging mutant and its use to produce helper-free defective retroviruses. Cell33:153-159, 1983
Библиографическая ссылка Palmiter RD , Norstedt G., Gelinas RE, et al: Metallothioneinhuman GH fusion genes stimulate growth of mice. Science 222:809-814, 1983
Библиографическая ссылка Hammer RE, Brinster RL, Rosenfeld MG, et al: Expression of human growth hormone-releasing factor in transgeneic mice results in increased somatic growth. Nature315:413-416, 1985
Библиографическая ссылка Oliff A., Defeo-Jones D., Boyer M., et al: Tumor secreting human TNF/cachectin induce cachexia in mice . Cell 50:555-563, 1987
Библиографическая ссылка Hanson RW, Hatzoglou M., McGrane MM, et al: Molecular biology and nutrition research. J Nutr119:957-964, 1989
Библиографическая ссылка Antonarakis SE: Diagnosis of genetic disorders at the DNA level. N Engl J Med. 320:153-163, 1989
Библиографическая ссылка Engleberg NC , Eisenstein BI: The impact of new cloning techniques on the diagnosis and treatment of infectious diseases. N Engl J Med 311:892-901, 1984
Библиографическая ссылка Pirastu M., Kan YW, Cao A., et al: Prenatal diagnosis of β-thalassemia. N Engl J Med309:284-287, 1983
Библиографическая ссылка Conner BJ, Reyes AA, Morin C., et al: Detection of sickle cell βsglobin allele by hybridization with synthetic oligonucleotides. Proc Natl Acad Sci80:278-282, 1983
Библиографическая ссылка Hobbs HH, Leitersdorf E., Goldstein JL, et al: Multiple crmmutations in familial hypercholesterolemia. J Clin Invest81:909-917,1988
Библиографическая ссылка Roberts RG, Bentley DR, Barby TFM, et al: Direct diagnosis of carriers of Duchenne and Becker muscular dystrophy by amplification of lymphocyte RNA. Lancet336:1523-1526, 1990
Библиографическая ссылка Itakura K., Hirose T., Crea R., et al: Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Science198:1056-1063, 1977
Библиографическая ссылка Goeddel DV, Kleid DG, Bolivar F., et al: Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci USA76:106-110, 1979
Библиографическая ссылка Goeddel DV, Heynecker HL, Hozumi T., et al: Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Nature281:544-548, 1979
Библиографическая ссылка Milner RDG : Growth hormone 1985. Br Med J 291:1593-1594, 1985
Библиографическая ссылка Fong Y., Rosenbaum M., Tracey KJ, et al: Recombinant growth ( hormone increases nitrogen accrual and myosin heavy chain mRNA expression. Proc Natl Acad Sci USA86:3371-3374, 1989
Библиографическая ссылка Hickey AR, Wenger TL, Carpenter VP, et al: Digoxin immune Fab ( therapy in the management of digitalis intoxication: Safety and efficacy results of an observational surveillance study. J Am Coll Cardiol17:590-598, 1991
Библиографическая ссылка Ziegler EJ, Fisher CJ, Sprung CL, et al: Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. N Engl J Med324:429-436, 1991
Библиографическая ссылка Dunn DL, Priest BP, Condie RM: Protective capacity of polyclonal and monoclonal antibodies directed against endotoxin during experimental sepsis. Arch Surg123:1389-1393, 1988
Библиографическая ссылка Tracey KJ, Fong Y., Hesse DG, et al: Anti-cachectin/TNF antibodies prevent the fatal sequelae of experimental bacteremia in primates. Nature330:662-664, 1987
Библиографическая ссылка Reichmann L. , Clark, M., Waldman H., et al: Reshaping human antibodies for therapy . Nature 332:323-327, 1988
Библиографическая ссылка Kohler G., Milstein C.: Continuous cultures of fused cells secreting antibody of predefined specificity . Nature 256:495-497, 1975
Библиографическая ссылка Mayforth RD , Quintans J.: Designer and catalytic antibodies . N Engl J Med 323:173-178, 1990
Библиографическая ссылка Morrison SL , Johnson MJ, Herzenberg LA, et al: Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains. Proc Natl Acad Sci USA 81:6851-6855, 1984
Библиографическая ссылка Jones PT, Dear PH, Foote J., et al: Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature321:522-525, 1986
Библиографическая ссылка Reichman L. , Clark M., Waldmann H., et al: Reshaping human antibodies for therapy . Nature 332:323-327, 1988
Библиографическая ссылка Sherry B., Gelin J., Fong Y., et al: Anticachectin/tumor necrosis factor-alpha antibodies attenuate the development of cachexia in two murine transplantable tumor models. FASEB J3:1956-1962, 1989
Библиографическая ссылка Queen C., Schneider WP, Selick HE, et al: A humanized antibody that binds to the interleukin 2 receptor . Proc Natl Acad Sci USA. 86:10029-10033, 1989
Библиографическая ссылка Hofmann SL, Russell DW, Brown MS, et al: Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgeneic mice. Science239:1277-1281, 1988
Библиографическая ссылка Selden RF, Skoskiewicz MJ, Russell PS, et al: Regulation of insulin-gene expression. N Engl J Med317:1067-1076, 1987
Библиографическая ссылка Wilson JM, Jefferson DM, Chowdhury JR, et al: Retrovirus-mediated transduction of adult hepatocytes. Proc Natl Acad Sci85:3014-3018, 1988
Библиографическая ссылка Wynshaw-Boris A., Lugo TG, Fournier REK, et al: Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells . J Biol Chem 259:12161-12169, 1984
Библиографическая ссылка Belmont JW, MacGregor GR, Wagner-Smith K., et al: Expression of human adenosine deaminase in murine hematopoietic cells. Mol Cell Biol8:5116-5125, 1988
Библиографическая ссылка Barr E., Leiden JM: Systemic delivery of recombinant proteins by genetically modified myoblasts . Science 254:1507-1509, 1991
Библиографическая ссылка Dhawan J., Pan LC, Pavlath GK, et al: Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science254:1509-1512, 1991
Библиографическая ссылка Cournoyer D. , Caskey CT: Gene transfer into humans. N Engl J Med 323:601-603, 1990
Библиографическая ссылка Dickson D.: NIH censure for Dr Martin Cline. Nature291:369, 1981
Библиографическая ссылка Williamson B.: Gene therapy. Nature298:417-418, 1981
Библиографическая ссылка Belmont JW, MacGregor GR, Wager-Smith K., et al: Expression of human adenosine deaminase in murine hematopoietic cells. Mol Cell Biol8:5116-5125, 1988
Библиографическая ссылка Culliton BJ : ADA gene therapy enters the competition. Science 249:975, 1990
Библиографическая ссылка Rosenberg SA , Aebersold P., Cornetta K., et al: Gene transfer into humans-Immunotherapy of patients with advanced melanoma, using tumor infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med 323:570-578, 1990
Библиографическая ссылка Culliton BJ : Gene therapy: Into the home stretch. Science 249:974-976, 1990
Библиографическая ссылка Roberts L.: New target for human gene therapy. Science241:906, 1988

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