| Автор | Beckley, Philip, D |
| Автор | Shinko, Paul, D |
| Автор | Sites, Jeffrey, P |
| Дата выпуска | 1997 |
| dc.description | The purpose of this study was to compare the air handling capability of five currently used membrane oxygenators: the Avecor Affinity™, the Bentley® SpiralGold™, the Medtronic Maxima Plus™, the Sarns Turbo™ and the Sorin Monolyth™ M. A circuit was constructed to include a hardshell venous reservoir and roller pump. Pressure monitoring sites and ultrasonic microbubble detection probes were located proximal and distal to the oxygenator. An air injection/infusion site was provided proximal to the roller pump inlet. Each circuit was primed with fresh anticoagulated bovine blood, adjusted to a haematocrit of 25% and maintained at 38 ± 1°C. Three different bolus amounts of air (10, 20 and 40 cm<sup>3</sup>) were injected at three blood flow rates (3, 4.5 and 6 l/min). A 1-min infusion of air delivered at 1 ml/s was also administered at three blood flow rates (3, 4.5 and 6 l/min). The hardshell reservoir was also completely emptied at each flow rate to simulate a massive air infusion.At any given blood flow, outlet microbubble counts were usually higher with greater bolus amounts of air. When indexed to the inlet bubble counts, the following average percent microbubbles were released from the outlet: Turbo™ 25%, Affinity™ 7%, Monolyth™ 5%, Maxima™ 3% and SpiralGold™ 1%. With a constant air infusion of 1 ml/s, greater outlet microbubble counts were associated with higher blood flow rates. Again, when indexed to the inlet bubble counts, the following average percent microbubbles were released from the outlet: Turbo™ 44%, Affinity™ 25%, Maxima™ 19%, Monolyth™ 16% and SpiralGold™ 0%. All oxygenators deprimed when the hardshell reservoir was emptied and all shed microbubbles into the outlet blood except the SpiralGold™.The results of this study indicate that air handling is not a simple function of blood flow pattern (i.e. top to bottom versus bottom to top), but also includes dynamics associated with oxygenator design, fibre arrangement and flow resistance. |
| Издатель | Sage Publications |
| Название | A comparison of gaseous emboli release in five membrane oxygenators |
| Тип | Journal Article |
| DOI | 10.1177/026765919701200208 |
| Print ISSN | 0267-6591 |
| Журнал | Perfusion |
| Том | 12 |
| Первая страница | 133 |
| Последняя страница | 141 |
| Аффилиация | Beckley, Philip, D, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio |
| Аффилиация | Shinko, Paul, D, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio |
| Аффилиация | Sites, Jeffrey, P, Cardiovascular and Extracorporeal Technologies, Plymouth, Minnesota |
| Выпуск | 2 |
| Библиографическая ссылка | Tovar EA, DelCampo C, Borsari A, Webb RP, Dell JR, Weinstein PB.Postoperative management of cerebral air embolism: gas physiology for surgeons. Ann Thorac Surg1995; 60: 1138-1142. |
| Библиографическая ссылка | Stoney WS, Alford Jr WC, Burrus GR, Glassford Jr DM, Thomas Jr CS.Air embolism and other accidents using pump oxygenators. Ann Thorac Surg1980; 29: 336-340. |
| Библиографическая ссылка | Mills NL, Ochsner JL.Massive air embolism during cardiopulmonary bypass: causes, prevention, and management. J Thorac Cardiovasc Surg1980; 80: 708-717. |
| Библиографическая ссылка | Kurusz M, Conti VR, Arens JF, Brown JP, Faulkner SC, Manning Jr JV.Perfusion accident survey. Proc Am Acad Cardiovasc Perf1986; 7: 57-65. |
| Библиографическая ссылка | Temple AP, Katz J.Air embolism: a potentially lethal surgical complication. AORN J1987; 45: 387-389. |
| Библиографическая ссылка | Mills SA.Cerebral injury and cardiac operations. Ann Thorac Surg1993; 56(5 suppl): S86-S91. |
| Библиографическая ссылка | Kurusz M.Gaseous microemboli: sources, causes, and clinical considerations. Med Instr1985; 19: 73-76. |
| Библиографическая ссылка | van Oeveren W, Dankert J, Wildevuur CR.Bubble oxygenation and cardiotomy suction impair the host defense during cardiopulmonary bypass: a study in dogs. Ann Thorac Surg1987; 44: 523-528. |
| Библиографическая ссылка | Gourlay T.The role of arterial line filters in perfusion safety. Perfusion1988; 3: 195-204. |
| Библиографическая ссылка | Campbell DE, Raskin SA.Cerebral dysfunction after cardiopulmonary bypass: aetiology, manifestations and interventions. Perfusion1990; 5: 251-260. |
| Библиографическая ссылка | Griffin S, Pugsley W, Treasure T.Microembolism during cardiopulmonary bypass: a comparison of bubble oxygenator with arterial line filter and membrane oxygenator alone. Perfusion1991; 6: 99-103. |
| Библиографическая ссылка | Kurusz M, Butler BD, Katz J, Conti VR.Air embolism during cardiopulmonary bypass. Perfusion1995; 10: 361-391. |
| Библиографическая ссылка | Hill AG, Groom RC, Vinansky RP, Speir AM, Macmanus Q, Lefrak EA.Gaseous microemboli and extracorporeal circulation. Proc Am Acad Cardiovasc Perf1986; 7: 131-137. |
| Библиографическая ссылка | Schabel RK, Berryessa RG, Justison GA, Tyndal CM, Schumann J.Ten common perfusion problems: prevention and treatment protocols. J Extra Corpor Technol1987; 19: 392-398. |
| Библиографическая ссылка | Cone JG, Hogan TM, Reed CCet al. Air embolism inhibition characteristics of arterial line filters: an in vitro study. Proc Am Acad Cardiovasc Perf1987; 8: 170-172. |
| Библиографическая ссылка | Padayachee TS, Parsons S, Theobold R, Gosling RG, Deverall PB.The effect of arterial filtration on reduction of gaseous microemboli in the middle cerebral artery during cardiopulmonary bypass. Ann Thorac Surg1988; 45: 647-649. |
| Библиографическая ссылка | Treasure T.Interventions to reduce cerebral injury during cardiac surgery - the effect of arterial line filtration. Perfusion1989; 4: 147-152. |
| Библиографическая ссылка | Deverall PB, Padayachee TS, Parsons S, Theobold R, Battistessa SA.Ultrasound detection of micro-emboli in the middle cerebral artery during cardiopulmonary bypass surgery. Eur J Cardiothorac Surg1988; 2: 256-260. |
| Библиографическая ссылка | Smith PLC.Interventions to reduce cerebral injury during cardiac surgery introduction and the effect of oxygenator type. Perfusion1989; 4: 139-145. |
| Библиографическая ссылка | Liu JF, Su ZK, Ding WX.Quantitation of particulate microemboli during cardiopulmonary bypass: experimental and clinical studies. Ann Thorac Surg1992; 54: 1196-1202. |
| Библиографическая ссылка | Johnston WE, Stump DA, DeWitt DSet al.Significance of gaseous microemboli in the cerebral circulation during cardiopulmonary bypass in dogs. Circulation1993; 88(5 Pt 2): II319-II329. |
| Библиографическая ссылка | Diesfeld T, Lajos TZ, Schimert G.Arterial venous bridge on cardiopulmonary bypass. J Cardiac Surg1994; 9: 128-130. |
| Библиографическая ссылка | Wheeldon DR, Bethune DW, Gill RD.Vortex pumping for routine cardiac surgery: a comparative study. Perfusion1990; 5: 135-143. |
| Библиографическая ссылка | Iatridis A, Chan T.Laboratory evaluations of vortex, centrifugal, and roller pump systems. Proc Am Acad Cardiovasc Perf1992; 13: 64-69. |
| Библиографическая ссылка | Pacheco DA, Ingram JM, Pacheco SL.A comparison of three centrifugal pumps’ ability to expel micro-air under conditions of cavitation or bolus air injection. Perfusion1995; 10: 361-391. |
| Библиографическая ссылка | Hatteland K, Pedersen T, Semb BKH.Comparison of bubble release from various types of oxygenators. Scand J Thorac Cardiovasc Surg1985; 19: 125-130. |
| Библиографическая ссылка | Sellman M, Ivert T, Stensved P, Hogberg M, Semb BKH.Doppler ultrasound estimation of microbubbles in the arterial line during extracorporeal circulation. Perfusion1990; 5: 23-32. |
| Библиографическая ссылка | Rhoades JR, French JS, Donaway J.Modification of a Terumo hollow fiber oxygenator to prevent massive air emboli. Proc Am Acad Cardiovasc Perf1987; 8: 52-55. |
| Библиографическая ссылка | Berryessa RG, Tyndal Jr CM, Osbourn D.An experimental evaluation of the Capiox 1.6 and 5.4M2 membrane oxygenators for air removal efficiency in the conventional and inverted positions. Proc Am Soc of Extra Corpor Technol1988; 19-22. |
| Библиографическая ссылка | Mehra AP, Akins A, Maisuria A, Glenville BE.Air handling characteristics of five membrane oxygenators. Perfusion1994; 9: 357-362. |
| Библиографическая ссылка | Fried DW, DeBenedetto BN, Zombolas TL, Leo JJ.Clinical evaluation of the Medtronic Maxima Plus membrane oxygenator. Perfusion1994; 9: 363-372. |
| Библиографическая ссылка | Vocelka CR, Thomas R, Kunzelman KS, Verrier E.An in vitro evaluation of Avecor’s Affinity hollow fiber membrane oxygenator. Proc Am Acad Cardiovasc Perf1994; 15: 70-72. |
| Библиографическая ссылка | Griffith KE, Vasquez MR, Beckley PD, LaLone BJ.Predicting oxygenator clinical performance from laboratory in-vitro testing. J Extra Corpor Technol1994; 26: 114-120. |
| Библиографическая ссылка | Adams D, Trpkosh T, Wooten D, Wright S.Evaluation of the Sorin Monolyth membrane oxygenator - our clinical experience. Proc Am Acad Cardiovasc Perf1995; 16: 49-50. |
| Библиографическая ссылка | Avecor cardiovascular Affinity hollow fiber oxygenator - instructions for use. Publication number 311. |
| Библиографическая ссылка | Medtronic cardiopulmonary Maxima Plus oxygenation system - instructions for use, 1993. |
| Библиографическая ссылка | Beckley PD, Morris SM, Smith JJ, McNamara JL, Novak JA.Comparison of the performance characteristics of three generations of membrane oxygenators: Univox, Univox Gold, and SpiralGold. Perfusion1996; 11: 31-40. |
