| Автор | McDuffie, Robert, S. |
| Автор | Heddleston, Leslie, N. |
| Автор | Blanton, Sandra, J. |
| Автор | Gibbs, Ronald, S. |
| Дата выпуска | 1995 |
| dc.description | Objective:To compare aztreonam in a standard dose with two gentamicin doses in the early treatment of experimental intra-amniotic infection in rabbits induced by intracervical inoculation with Escherichia coli.Methods:Timed pregnant rabbits on day 21 (70% of gestation) were inoculated intracervically with 10<sup>4</sup>-10<sup>5</sup> colony-forming units of E coli. After inoculation, the animals were treated with one of three regimens: 1) aztreonam at 90 mg/kg/day (“standard” dose in humans), 2) gentamicin at 4.5 mg/kg/day (“standard” dose in humans), or 3) higher-dose gentamicin at 6.0 mg/kg/day, each given in three divided doses daily. Outcomes included fever, delivery, and presence of a live fetus. At necropsy, cultures were taken from endometrium, amniotic fluid, and blood. Data were analyzed by Fisher exact test because the expected cell size was fewer than five.Results:Compared with rabbits treated with aztreonam, those treated with gentamicin 4.5 mg/kg/day delivered significantly more often (P = .002), had more positive cultures (P < .001), and had significantly fewer live fetuses (P < .001). Compared with rabbits treated with gentamicin 6.0 mg/kg/day, those treated with gentamicin 4.5 mg/kg/day delivered more often (P = .003), had fewer live fetuses (P = .02), and had more positive cultures (P = .02). There were no significant differences between the aztreonam and gentamicin 6.0 mg/kg/day groups.Conclusions:This study demonstrates in an animal model that aztreonam and gentamicin at 6.0 mg/kg/day are more effective than gentamicin at 4.5 mg/kg/day (a dose that is widely used empirically in humans) in the early treatment of experimental intra-amniotic infection in rabbits. Aztreonam was as effective as gentamicin at 6.0 mg/kg/day. In this rabbit model, in which intra-amniotic infection is accompanied by maternal sepsis, 4.5 mg/kg/day of gentamicin was not adequate for the treatment of severe maternal infection. |
| Издатель | Sage Publications |
| Тема | Intra-amniotic infection |
| Тема | animal model |
| Тема | pregnancy |
| Тема | gentamicin |
| Тема | aztreonam |
| Название | A Comparison of Aztreonam and Two Regimens of Gentamicin in a Rabbit Model of Intra-Amniotic Infection and Sepsis |
| Тип | Journal Article |
| DOI | 10.1177/107155769500200105 |
| Print ISSN | 1071-5576 |
| Журнал | Journal of the Society for Gynecologic Investigation |
| Том | 2 |
| Первая страница | 23 |
| Последняя страница | 25 |
| Аффилиация | Gibbs, Ronald, S., Departments of Obstetrics and Gynecology, Kaiser Permanente and Saint Joseph Hospital, Denver; University of Colorado Health Sciences Center, Denver, Colorado |
| Выпуск | 1 |
| Библиографическая ссылка | 1. Gibbs RS, Duff P. Progress in pathogenesis and management of clinical inta-amniotic infection. Am J Obstet Gynecol 1991;164:1317-1326. |
| Библиографическая ссылка | 2. Duff P, Jorgensen JH, Gibbs RS, Blanco JD, Alexander G, Castaneda YS. Serum gentamicin levels in patients with post-cesarean endomyometritis. Obstet Gynecol 1983;61:723-727. |
| Библиографическая ссылка | 3. Zaske DE, Cipolle RJ, Strate RG, Malo JW, Koszalka MF. Rapid gentamicin elimination in obstetric patients. Obstet Gynecol 1980;56:559-564. |
| Библиографическая ссылка | 4. McDuffie RS, Blanton SJ, Shikes RH, Gibbs RS. A rabbit model for bacterially induced preterm pregnancy loss: Intervention studies with ampicillin-sulbactam. Am J Obstet Gynecol 1991;165:1568-1574. |
| Библиографическая ссылка | 5. McDuffie RS, Sherman MP, Gibbs RS. Amniotic fluid tumor necrosis factor-α and interleukin-1 in a rabbit model of bacterially-induced preterm pregnancy loss. Am J Obstet Gynecol 1992;167:1583-1588. |
| Библиографическая ссылка | 6. Heddleston L, McDuffie RS, Gibbs RS. A rabbit model for ascending infection in pregnancy: Intervention with indomethacin and delayed ampicillin-sulbactam therapy. Am J Obstet Gynecol 1993;169:708-712. |
| Библиографическая ссылка | 7. Weinstein AJ, Gibbs RS, Gallagher M. Placental transfer of clindamycin and gentamicin in term pregnancy. Am J Obstet Gynecol 1976;124:688-691. |
| Библиографическая ссылка | 8. Lazebnik N, Noy S, Lazebnik R, Hezroni Y, Amoday I, Aviram A. Gentamicin serum half-life: A comparison between pregnant and non-pregnant women. Postgrad Med J 1985;61:979-981. |
| Библиографическая ссылка | 9. Gibbs RS, Dinsmoor MJ, Newton ER, Ramamurthy RS. A randomized trial of intrapartum versus immediate post-partum treatment of women with intra-amniotic infection. Obstet Gynecol 1988;72:823-828. |
