| Автор | Lail-Trecker, Melissa |
| Автор | Gulati, Rita |
| Автор | Peluso, John, J. |
| Дата выпуска | 1998 |
| dc.description | Objective:To review data regarding the expression, function, and signal transduction pathways associated with hepatocyte growth factor/scatter factor (HGF/SF) as related to normal and neoplastic cells of reproductive tissues.Methods:Studies involving HGF/SF were reviewed and the data were summarized.Results:Hepatocyte growth factor/scatter factor is generally expressed within the stromal components of the testis, prostate, placenta, mammary gland, uterine endometrium, and ovary. The receptor for HGF/SF, c-met, is expressed in the epithelial cells of these tissues. Ligand activation of c-met results in its autotyrosine phosphorylation and the subsequent stimulation of numerous signal transduction pathways. Which pathways are activated determine in part the effect that HGF/SF has on a specific tissue. Hepatocyte growth factor/scatter factor can promote a variety of biologic responses including mitosis, motogenesis (ie, cell movement), differentiation, and apoptosis. In addition, both HGF/SF and c-met continue to be expressed during the neoplastic transformation of cells from these reproductive tissues.Conclusion:Hapatocyte growth factor/scatter factor plays an important role in regulating the physiologic function of several reproductive tissues and may also be involved in the oncogenesis of cells within these tissues. |
| Издатель | Sage Publications |
| Тема | Hepatocyte growth factor |
| Тема | c-met |
| Тема | testis |
| Тема | prostate |
| Тема | placenta |
| Название | A Role for Hepatocyte Growth Factors/Scatter Factor in Regulating Normal and Neoplastic Cells of Reproductive Tissues |
| Тип | Journal Article |
| DOI | 10.1177/107155769800500302 |
| Print ISSN | 1071-5576 |
| Журнал | Journal of the Society for Gynecologic Investigation |
| Том | 5 |
| Первая страница | 114 |
| Последняя страница | 121 |
| Аффилиация | Gulati, Rita, Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut |
| Аффилиация | Peluso, John, J., Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, CT 06030 peluso@nso2.uchc.edu |
| Выпуск | 3 |
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