Abdominal Aortic Aneurysms in Familial Hypercholesterolemia—Case Reports
Kita Yoshihito; Shimizu Masami; Sugihara Norihiko; Shimizu Kuniyoshi; Miura Motohiro; Koizumi Junichi; Mabuchi Hiroshi; Takeda Ryoyu
Журнал:
Angiology
Дата:
1993-06-01
Аннотация:
Familial hypercholesterolemia (FH) is a genetic disease characterized by
high serum cholesterol levels and premature coronary atherosclerosis. Hyper
cholesterolemia is one of the factors promoting the arteriosclerotic process and
is a major cause of aortic aneurysm. Few data are available, however, about
abdominal aortic aneurysms (AAAs) in patients with FH. In this study, the clini
cal and angiographic characteristics of AAAs found in patients with FH were
investigated. Thirty-one cases (23 men, 8 women, aged fifty ± fourteen years)
were examined by coronary angiography, thoracic and abdominal aortography,
and clinical data. Abdominal aortography detected abdominal aneurysms in 8
cases (26%), all of whom were men, including 4 cases (50%) that were compli
cated by diabetes mellitus. The abdominal aneurysm patients manifested severe
coronary atherosclerosis, severe abdominal aortic irregularity, and higher
blood pressure than the nonaneurysm FH patients. These findings suggest that
AAAs are an important and prevalent feature in FH, especially in men with
diabetes mellitus and high blood pressure.
865.1Кб