| Автор | Gaw, Alasdair, J. |
| Автор | Aberdeen, Judy |
| Автор | Humphrey, Patrick, P. A. |
| Автор | Wadsworth, Roger, M. |
| Автор | Burnstock, Geoffrey |
| Дата выпуска | 1990 |
| dc.description | Using immunohistochemical labeling, a dense noradrenergic innervation was observed within the wall of the sheep middle cerebral artery, but there was no evidence of serotoninergic nerves. Following preincubation with 5-hydroxytryptamine (5-HT), immunoreactivity to 5-HT was observed in nerve fibers, which appeared to be a consequence of uptake into noradrenergic nerves. Radiolabeled uptake studies provided evidence for the existence of two neuronal uptake mechanisms for 5-HT: one that was selectively inhibited by citalopram and one that was selectively inhibited by desipramine. The desipramine-sensitive mechanism had a greater affinity for noradrenaline than 5-HT, and desipramine caused a greater degree of inhibition of 5-HT uptake than citalopram. This study shows that, in the sheep middle cerebral artery, 5-HT is taken up into noradrenergic nerves by two distinct uptake mechanisms. |
| Издатель | SAGE Publications |
| Тема | Immunohistochemistry |
| Тема | noradrenergic innervation |
| Тема | serotoninergic innervation |
| Тема | 5-HT uptake |
| Тема | middle cerebral artery |
| Название | Characterization of 5-Hydroxytryptamine Uptake Mechanisms in the Sympathetic Perivascular Nerves of the Sheep Middle Cerebral Artery |
| Тип | Journal Article |
| DOI | 10.1177/104252689000200605 |
| Print ISSN | 1042-5268 |
| Журнал | Journal of Vascular Medicine and Biology |
| Том | 2 |
| Первая страница | 299 |
| Последняя страница | 305 |
| Выпуск | 6 |
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