Acute Effects of Ethanol on Motor Performance and Movement-Related Brain Potentials
Rohrbaugh, John W.; Stapleton, June M.; Frowein, Henri W.; Adinoff, Bryon; Varner, Jerald L.; Lane, Elizabeth A.; Eckardt, Michael J.; Linnoila, Markku; Rohrbaugh, John W.; Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, NIH Clinical Center, Bethesda, MD, 20892; Stapleton, June M.; Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Abuse and Alcoholism, NIH Clinical Center, Bethesda, MD, 20892; Frowein, Henri W.; PTT Centrale Direktie, The Hague, The Netherlands; Adinoff, Bryon; Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, NIH Clinical Center, Bethesda, MD, 20892; Varner, Jerald L.; Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, NIH Clinical Center, Bethesda, MD, 20892; Lane, Elizabeth A.; Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, NIH Clinical Center, Bethesda, MD 20892; Eckardt, Michael J.; Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, NIH Clinical Center, Bethesda, MD, 20892; Linnoila, Markku; Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, NIH Clinical Center, Bethesda, MD 20892
Журнал:
Advances in Alcohol & Substance Abuse
Дата:
1988
Аннотация:
The acute effects of ethanol on skilled motor functions were examined in male social drinkers, under four doses raning from 0 (placebo) to 1.05 g/kg lean body weight. The movement entailed a forewarned choice transitive motion of the arm and hand, aimed at a flanking target. Performance measures disclosed only small effects of ethanol on speed and accuracy of movement. The simultaneously-recorded movement-related brain potentials disclosed decreased involvement of frontal and posterior brain areas, suggesting that ethanol disrupted the planning and regulation of movement despite the overall preservation of reaction speed.
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