| Автор | Eckert, Debra M. |
| Автор | Kim, Peter S. |
| Дата выпуска | 2001 |
| dc.description | ▪ Abstract Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical studies of two viral glycoproteins, influenza hemagglutinin and HIV-1 envelope protein, have led to a common model for viral entry. The fusion mechanism involves a transient conformational species that can be targeted by therapeutic strategies. This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | MECHANISMS OF VIRAL MEMBRANE FUSION AND ITS INHIBITION |
| DOI | 10.1146/annurev.biochem.70.1.777 |
| Print ISSN | 0066-4154 |
| Журнал | Annual Review of Biochemistry |
| Том | 70 |
| Первая страница | 777 |
| Последняя страница | 810 |
| Аффилиация | Eckert, Debra M.; Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, M.I.T., Cambridge, Massachusetts 02142; e-mail: Eckert@wi.mit.edu peter_kim@merck.com |
