| Автор | Davis, Mark M. |
| Автор | Krogsgaard, Michelle |
| Автор | Huppa, Johannes B. |
| Автор | Sumen, Cenk |
| Автор | Purbhoo, Marco A. |
| Автор | Irvine, Darrell J. |
| Автор | Wu, Lawren C. |
| Автор | Ehrlich, Lauren |
| Дата выпуска | 2003 |
| dc.description | ▪ Abstract Recognition of foreign antigens by T lymphocytes is a very important component of vertebrate immunity—vital to the clearance of pathogenic organisms and particular viruses and necessary, indirectly, for the production of high affinity antibodies. T cell recognition is mediated by the systematic scanning of cell surfaces by T cells, which collectively express many antigen receptors. When the appropriate antigenic peptide bound to a molecule of the major histocompatibility complex is found—even in minute quantities—a series of elaborate cell-surface molecule and internal rearrangements take place. The sequence of events and the development of techniques required to observe these events have significantly enhanced our understanding of T cell recognition and may find application in other systems of transient cell:cell interactions as well. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | DYNAMICS OF CELL SURFACE MOLECULES DURING T CELL RECOGNITION |
| DOI | 10.1146/annurev.biochem.72.121801.161625 |
| Print ISSN | 0066-4154 |
| Журнал | Annual Review of Biochemistry |
| Том | 72 |
| Первая страница | 717 |
| Последняя страница | 742 |
| Аффилиация | Davis, Mark M.; Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University, Stanford, California 94305-5323; email: mdavis@cmgm.stanford.edu , mkrogsgd@cmgm.stanford.edu , jhuppa@cmgm.stanford.edu , csumen@stanford.edu , purbhoo@cmgm.stanford.edu |
