USING PROTEIN FOLDING RATES TO TEST PROTEIN FOLDING THEORIES
Gillespie, Blake; Plaxco, Kevin W.; Gillespie, Blake; Department of Chemistry and Biochemistry, 2Interdepartmental Program in Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, California 93106; e-mail: blakeg@chem.ucsb.edu , kwp@chem.ucsb.edu
Журнал:
Annual Review of Biochemistry
Дата:
2004
Аннотация:
▪ Abstract The fastest simple, kinetically two-state protein folds a million times more rapidly than the slowest. Here we review many recent theories of protein folding kinetics in terms of their ability to qualitatively rationalize, if not quantitatively predict, this fundamental experimental observation.
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