| Автор | Ríos, Eduardo |
| Автор | Stern, Michael D. |
| Дата выпуска | 1997 |
| dc.description | ▪ Abstract Researchers have made good progress in unraveling the molecular mechanisms of excitation-contraction (EC) coupling in striated muscle. Despite this progress, paradoxes abound. In skeletal muscle, the existence of a mechanical coupling between membrane charge movement and activation of sarcoplasmic reticulum (SR) release channels is essentially established, but the contribution of Ca<sup>2+</sup>-induced Ca<sup>2+</sup> release (CICR) to the transient and steady-state components of Ca<sup>2+</sup> release remains controversial. In cardiac muscle, the role of CICR as the primary mechanism of EC coupling is well established, but the stability and tight coupling between membrane Ca<sup>2+</sup> current and release are paradoxical. Answers may lie in microdomain issues, and in the examination of discrete elementary release events, although quantitative treatments are needed. This review explores the theoretical and experimental methods used and the observations made in the study of microdomain Ca<sup>2+</sup>. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | CALCIUM IN CLOSE QUARTERS:Microdomain Feedback in Excitation-Contraction Coupling and Other Cell Biological Phenomena |
| DOI | 10.1146/annurev.biophys.26.1.47 |
| Print ISSN | 1056-8700 |
| Журнал | Annual Review of Biophysics and Biomolecular Structure |
| Том | 26 |
| Первая страница | 47 |
| Последняя страница | 82 |
| Аффилиация | Ríos, Eduardo; Department of Molecular Biophysics and Physiology, Rush University, Chicago, Illinois 60612; e-mail: erios@rush.edu |
