| Автор | Nakamoto, Robert K. |
| Автор | Ketchum, Christian J. |
| Автор | Al-Shawi, Marwan K. |
| Дата выпуска | 1999 |
| dc.description | ▪ Abstract The F0F1 ATP synthase is a large multisubunit complex that couples translocation of protons down an electrochemical gradient to the synthesis of ATP. Recent advances in structural analyses have led to the demonstration that the enzyme utilizes a rotational catalytic mechanism. Kinetic and biochemical evidence is consistent with the expected equal participation of the three catalytic sites in the α3β3 hexamer, which operate in sequential, cooperative reaction pathways. The rotation of the core γ subunit plays critical roles in establishing the conformation of the sites and the cooperative interactions. Mutational analyses have shown that the rotor subunits are responsible for coupling and in doing so transmit specific conformational information between transport and catalysis. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | ROTATIONAL COUPLING IN THE F0F1 ATP SYNTHASE |
| DOI | 10.1146/annurev.biophys.28.1.205 |
| Print ISSN | 1056-8700 |
| Журнал | Annual Review of Biophysics and Biomolecular Structure |
| Том | 28 |
| Первая страница | 205 |
| Последняя страница | 234 |
| Аффилиация | Nakamoto, Robert K.; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22906; e-mail: rkn3c@virginia.edu , cketchum@welchlink.welch.jhu.edu , ma9a@virginia.edu |
