| Автор | Loll, Patrick J. |
| Автор | Axelsen, Paul H. |
| Дата выпуска | 2000 |
| dc.description | ▪ Abstract Vancomycin is the archetype among naturally occurring compounds known as glycopeptide antibiotics. Because it is a vital therapeutic agent used worldwide for the treatment of infections with gram-positive bacteria, emerging bacterial resistance to vancomycin is a major public health threat. Recent investigations into the mechanisms of action of glycopeptide antibiotics are driven by a need to understand their detailed mechanism of action so that new agents can be developed to overcome resistance. These investigations have revealed that glycopeptide antibiotics exhibit a rich array of complex cooperative phenomena when they bind target ligands, making them valuable model systems for the study of molecular recognition. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | THE STRUCTURAL BIOLOGY OF MOLECULAR RECOGNITION BY VANCOMYCIN |
| DOI | 10.1146/annurev.biophys.29.1.265 |
| Print ISSN | 1056-8700 |
| Журнал | Annual Review of Biophysics and Biomolecular Structure |
| Том | 29 |
| Первая страница | 265 |
| Последняя страница | 289 |
| Аффилиация | Loll, Patrick J.; Departments of Pharmacology* and Medicine†, Infectious Disease Section, The Johnson Foundation for Molecular Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084; e-mail: loll@pharm.med.upenn.edu , axe@pharm.med.upenn.edu |
