| Автор | Gall, Joseph G. |
| Дата выпуска | 2000 |
| dc.description | ▪ Abstract Cajal bodies are small nuclear organelles first described nearly 100 years ago by Ramón y Cajal in vertebrate neural tissues. They have since been found in a variety of animal and plant nuclei, suggesting that they are involved in basic cellular processes. Cajal bodies contain a marker protein of unknown function, p80-coilin, and many components involved in transcription and processing of nuclear RNAs. Among these are the three eukaryotic RNA polymerases and factors required for transcribing and processing their respective nuclear transcripts: mRNA, rRNA, and pol III transcripts. A model is discussed in which Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. A parallel is drawn to the nucleolus and the preassembly of ribosomes, which are unitary particles involved in translation of proteins. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | CAJAL BODIES: The First 100 Years |
| DOI | 10.1146/annurev.cellbio.16.1.273 |
| Print ISSN | 1081-0706 |
| Журнал | Annual Review of Cell and Developmental Biology |
| Том | 16 |
| Первая страница | 273 |
| Последняя страница | 300 |
| Аффилиация | Gall, Joseph G.; Department of Embryology, Carnegie Institution, Baltimore, Maryland 21210; e-mail: gall@ciwemb.edu |
