| Автор | Owen, David J. |
| Автор | Collins, Brett M. |
| Автор | Evans, Philip R. |
| Дата выпуска | 2004 |
| dc.description | ▪ Abstract Clathrin-coated vesicles (CCVs) are responsible for the transport of proteins between various compartments of the secretory and endocytic systems. Clathrin forms a scaffold around these vesicles that is linked to membranes by clathrin adaptors. The adaptors simultaneously bind to clathrin and to transmembrane proteins and/or phospholipids and can also interact with each other and with other components of the CCV formation machinery. The result is a collection of proteins that can make multiple, moderate strength (μM Kd) interactions and thereby establish the dynamic regulatable networks to drive vesicle genesis at the correct time and place in the cell. This review focuses on the structure of clathrin adaptors and how these structures provide functional information on the mechanism of CCV formation. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | ADAPTORS FOR CLATHRIN COATS: Structure and Function |
| DOI | 10.1146/annurev.cellbio.20.010403.104543 |
| Print ISSN | 1081-0706 |
| Журнал | Annual Review of Cell and Developmental Biology |
| Том | 20 |
| Первая страница | 153 |
| Последняя страница | 191 |
| Аффилиация | Owen, David J.; Cambridge Institute for Medical Research, University of Cambridge, Department of Clinical Biochemistry , Cambridge, CB2 2XY , UK ; email: bmc25@cam.ac.uk ; djo30@cam.ac.uk . |
