| Автор | Rybak, Michael J. |
| Автор | Boike, Steven C. |
| Автор | Levine, Donald P. |
| Автор | Erickson, Steven R. |
| Дата выпуска | 1986 |
| dc.description | The effects and toxicity of tobramycin were assessed in 26 patients receiving high-dose (approximately 8 mg/kg/d) therapy for pseudomonal endocarditis or conventional-dose (approximately 3 mg/kg/d) therapy for various systemic Gram-negative infections. Patients in the high-dose group received an average of 29.5 g of drug over 49 days and the dosage was adjusted to maintain peak serum concentrations of 15–20 mg/l. In the conventional-dose group, patients received an average of 8.6 g of tobramycin over 26.7 days and the dosage was adjusted to achieve peak concentrations of 4–10 mg/1. Clinical evidence of acute renal failure was not apparent in any patient. Five of seven patients in the high-dose group, for whom audiologic data was available, exhibited loss of hearing sensitivity in the high frequency range, but no patients sustained significant reduction in hearing in the conversational frequency range. Patients receiving high-dose tobramycin do not appear to be at greater risk for development of nephrotoxicity than do patients receiving conventional-dose therapy. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © 1986 The British Society for Antimicrobial Chemotherapy |
| Тема | Original Articles |
| Название | Clinical use and toxicity of high-dose tobramycin in patients with pseudomonal endocarditis |
| Тип | research-article |
| Electronic ISSN | 1460-2091 |
| Print ISSN | 0305-7453 |
| Журнал | Journal of Antimicrobial Chemotherapy |
| Том | 17 |
| Первая страница | 115 |
| Последняя страница | 120 |
| Аффилиация | Rybak Michael J.; Department of Pharmacy and the Division of Infectious Diseases, University Health Center, and Wayne State University |
| Аффилиация | Boike Steven C.; Department of Pharmacy and the Division of Infectious Diseases, University Health Center, and Wayne State University |
| Аффилиация | Levine Donald P.; Department of Medicine, Detroit Receiving Hospital and University Health Center, and Wayne State University |
| Аффилиация | Erickson Steven R.; Department of Pharmacy and the Division of Infectious Diseases, University Health Center, and Wayne State University |
| Выпуск | 1 |
