| Автор | Gilman, S. |
| Автор | Saunders, Venetia A. |
| Дата выпуска | 1986 |
| dc.description | Accumulation of gentamicin by gentamicin-susceptible Staphylococcus aureus was examined by using the ionophorous antibiotic, valinomycin and the proton-translocating ATPase inhibitor N,N′-dicyclohexylcarbodiimide. The effects of these inhibitors on the transmembrane electrical potential (Δψ) were determined by measuring the equilibrium distribution of the tetraphenylphosphonium ion. The results indicate a direct correlation between Δψ and the extent of gentamicin uptake. However, under conditions where a significant Δψ existed across the plasma membrane, uptake of gentamicin was negligible. A threshold Δψ may thus be required to initiate gentamicin uptake. The proposed threshold Δψ appears to vary depending upon the external concentration of gentamicin. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © 1986 The British Society for Antimicrobial Chemotherapy |
| Тема | Original Articles |
| Название | Accumulation of gentamicin by Staphylococcus aureus: the role of the transmembrane electrical potential |
| Тип | research-article |
| Electronic ISSN | 1460-2091 |
| Print ISSN | 0305-7453 |
| Журнал | Journal of Antimicrobial Chemotherapy |
| Том | 17 |
| Первая страница | 37 |
| Последняя страница | 44 |
| Аффилиация | Department of Biology, Liverpool PolytechnicByrom Street, Liverpool L3 3AF, England |
| Выпуск | 1 |
