| Автор | Shinkai, Tetsu |
| Автор | Saijo, Nagahiro |
| Автор | Eguchi, Kenji |
| Автор | Sasaki, Yasutsuna |
| Автор | Tamura, Tomohide |
| Автор | Fujiwara, Yasuhiro |
| Автор | Mae, Masahiro |
| Автор | Fukuda, Masaaki |
| Автор | Ohe, Yuichiro |
| Автор | Sasaki, Satoru |
| Автор | Nakagawa, Kazuhiko |
| Автор | Minato, Koichi |
| Автор | Hong, Weon-Seon |
| Автор | Suemasu, Keiichi |
| Дата выпуска | 1989 |
| dc.description | Forty-two patients with advanced lung cancer undergoing chemotherapy containing cisplatin (80 mg/m<sup>2</sup> were submitted to a randomized controlled trial to evaluate the effect of the combination of metoclopramide and dexamethasone for the treatment of delayed cisplatin-induced emesis occuring more than 24 hours after cisplatin administration. All patients received intravenously (i.v.) high-dose metoclopramide and dexamethasone on the day of cisplatin treatment. Excellent emetic control (no emesis during the 24 hours following cisplatin administration) was achieved in 30 out of 41 patients (73%) with this combination. Patients treated i.v. with metoclopramide and dexarnethasone on days 2–7 experienced less delayed emesis, nausea and anorexia compared to those treated with a placebo (delayed emesis, 25 vs 50%, respectively, P=0.105; more than four days of nausea, 10 vs 35%, respectively, P=0.059; less than three days of anorexia, 80 vs 50%, respectively, P=0.048). Although the results of the study showed no statistically significant advantage with the combination of i.v. metoclopramide and dexamethasone for delayed emesis, we recommended the use of i.v. metoclopramide plus dexamethasone for patients treated with cisplatin, in view of the short duration of anorexia and the marginal reduction in nausea. Female patients tended to have more emetic episodes and extrapyramidal side effects (except akathisia) than male patients, but the differences were not statistically significant except for acute emesis (P<0.005) |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Oxford University Press |
| Тема | Antiemetics |
| Тема | Cisplatin |
| Тема | Delayed emesis |
| Тема | Original Articles |
| Название | Control of Cisplatin-induced Delayed Emesis with Metoclopramide and Dexamethasone: a Randomized Controlled Trial |
| Тип | research-article |
| Electronic ISSN | 1465-3621 |
| Print ISSN | 0368-2811 |
| Журнал | Japanese Journal of Clinical Oncology |
| Том | 19 |
| Первая страница | 40 |
| Последняя страница | 44 |
| Аффилиация | Shinkai Tetsu; Department of Internal Medicine |
| Аффилиация | Saijo Nagahiro; Department of Internal Medicine |
| Аффилиация | Eguchi Kenji; Department of Internal Medicine |
| Аффилиация | Sasaki Yasutsuna; Department of Internal Medicine |
| Аффилиация | Tamura Tomohide; Department of Internal Medicine |
| Аффилиация | Fujiwara Yasuhiro; Department of Internal Medicine |
| Аффилиация | Mae Masahiro; Department of Internal Medicine |
| Аффилиация | Fukuda Masaaki; Department of Internal Medicine |
| Аффилиация | Ohe Yuichiro; Department of Internal Medicine |
| Аффилиация | Sasaki Satoru; Department of Internal Medicine |
| Аффилиация | Nakagawa Kazuhiko; Pharmacology Division National Cancer Center Research Institute |
| Аффилиация | Minato Koichi; Pharmacology Division National Cancer Center Research Institute |
| Аффилиация | Hong Weon-Seon; Department of Internal Medicine, Korea Cancer Center Hospital |
| Аффилиация | Suemasu Keiichi; Surgery, National Cancer Center Hospital |
| Выпуск | 1 |
