| Автор | Almahbobi, Ghanim |
| Автор | Nagodavithane, Anjalee |
| Автор | Trounson, Alan O. |
| Дата выпуска | 1995 |
| dc.description | The effects of epidermal growth factor (EGF), transforming growth factor alpha (TGFα) and androstenedione on follicular growth and oestradiol production were studied in cultured mouse preantral follicles. Cultured follicles in the control group showed growth and steroidogenic capacities up to the antral follicle stage day 4 of culture. However, many of these follicles failed to resume their growth during the culture. Increasing concentrations of EGF and TGFα decreased the number of follicles reaching the large antral stage at day of culture. All treatments with EGF, TGFα and androstenedione caused significant inhibitions in both follicular growth and oestradiol production, regardless of the dose used (1–20 ng/ml). Moreover, no synergistic effect between androstenedione and either of the two growth factors was observed. These results suggest that EGF, TGFα and/or androstenedione may play important roles in the modulation of gonadotrophin-controlled ovarian function. The effects observed in this study suggest that the aberration in the regulation of these growth factors may result in the creation and maintenance of certain ovarian disorders, such as the polycystic ovarian disease. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Oxford University Press |
| Тема | EGF |
| Тема | follicle |
| Тема | mouse |
| Тема | PCO |
| Тема | TGFα |
| Тема | Article |
| Название | Effects of epidermal growth factor, transforming growth factor α and androstenedione on follicular growth and aromatization in culture |
| Тип | research-article |
| Electronic ISSN | 1460-2350 |
| Print ISSN | 0268-1161 |
| Журнал | Human Reproduction |
| Том | 10 |
| Первая страница | 2767 |
| Последняя страница | 2772 |
| Аффилиация | Laboratories of Human and Animal Reproductive Biology, Institute of Reproduction and Development, Monash UniversityClayton, Victoria 3168, Australia |
| Выпуск | 10 |
