| Автор | Abdel-Rahman, Burae |
| Автор | Fiddler, Morris |
| Автор | Rappolee, Daniel |
| Автор | Pergament, Eugene |
| Дата выпуска | 1995 |
| dc.description | Utilizing a sensitive reverse transcriptase-polymerase chain reaction (RT-PCR) assay system, the time course of mRIMA expression of two transcription regulators, OCT4 and OCT6, was assessed in individual preimplantation human embryos. Examination of ova with three pronuclei and 1-cell through blastocyst stage embryos revealed that OCT4 mRNA was continuously expressed between the time of fertilization and 10+ cell stages, whereas OCT6 mRNA expression was not observed until the 10+ cell stage. The difference in the time of expression of OCT4 mRNA and OCT6 mRNA indicates that the two genes play differential roles in human embryogenesis. Nucleotide sequence homology for OCT4 and OCT6 among mammalian organisms supports the concept that genetic elements determining developmental events during embryogenesis are conserved in evolution. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Oxford University Press |
| Тема | OCT4 |
| Тема | OCT6 |
| Тема | POU-domain |
| Тема | reverse transcriptase |
| Тема | Article |
| Название | Expression of transcription regulating genes in human preimplantation embryos |
| Тип | research-article |
| Electronic ISSN | 1460-2350 |
| Print ISSN | 0268-1161 |
| Журнал | Human Reproduction |
| Том | 10 |
| Первая страница | 2787 |
| Последняя страница | 2792 |
| Аффилиация | Abdel-Rahman Burae; department of Obstetrics and Gynecology, Section of Reproductive Genetics, Northwestern University Medical School, Prentice Women's Hospital and Maternity Center, |
| Аффилиация | Fiddler Morris; DePaul University, School for New Learning |
| Аффилиация | Rappolee Daniel; department of Obstetrics and Gynecology, Section of Reproductive Genetics, Northwestern University Medical School, Prentice Women's Hospital and Maternity Center,; DePaul University, School for New Learning |
| Аффилиация | Pergament Eugene; department of Obstetrics and Gynecology, Section of Reproductive Genetics, Northwestern University Medical School, Prentice Women's Hospital and Maternity Center, |
| Выпуск | 10 |
