| Автор | Bemis, David A. |
| Автор | Kennedy, John R. |
| Дата выпуска | 1981 |
| dc.description | Ciliated epithelial cell outgrowths from canine tracheal explants were used to study the interaction between Bordetella bronchiseptica and canine respiratory cilia. A sensitive system for quantitating the ciliary beat frequencies of an individual cell was used to study the effects of B. bronchiseptica on ciliary function. Phase I and intermediatephase B. bronchiseptica isolates produced significant reductions (⩾50%) in ciliary beat frequencies within 5 min and nearly complete ciliostasis within 3 hr. A rough-phase isolate of B. bronchiseptica and heat- and formalin-killed preparations of the phase I isolate had no ciliostatic effect. Phase I and intermediate-phase isolates attached to cilia, whereas the rough-phase isolate did not. The ciliostatic effects of the phase I isolate could not be reproduced with endotoxin or culture supernatants from the organism. Thus, attachment alone does not produce ciliostasis; ciliostatic effects of Bordetella may require the close association between metabolically active organisms and cilia. |
| Формат | application.pdf |
| Издатель | The University of Chicago Press |
| Копирайт | © 1981 by The University of Chicago |
| Тема | Original Articles |
| Название | An Improved System for Studying the Effect of Bordetella bronchiseptica on the Ciliary Activity of Canine Tracheal Epithelial Cells |
| Тип | research-article |
| DOI | 10.1093/infdis/144.4.349 |
| Electronic ISSN | 1537-6613 |
| Print ISSN | 0022-1899 |
| Журнал | The Journal of Infectious Diseases |
| Том | 144 |
| Первая страница | 349 |
| Последняя страница | 357 |
| Аффилиация | Bemis David A.; Department of Microbiology, University of Tennessee; Department of Zoology, University of Tennessee |
| Аффилиация | Kennedy John R.; Department of Microbiology, University of Tennessee; Department of Zoology, University of Tennessee |
| Выпуск | 4 |
