| Автор | Bachouchi, Mounir |
| Автор | Cvitkovic, Esteban |
| Автор | Azli, Nasser |
| Автор | Gasmi, Jamal |
| Автор | Cortes-Funes, Hernan |
| Автор | Boussen, Hamouda |
| Автор | Rahal, Mohamed |
| Автор | Kalifa, Chantal |
| Автор | Schwaab, Guy |
| Автор | Eschwege, Francois |
| Автор | Wibault, Pierre |
| Автор | Armand, Jean Pierre |
| Дата выпуска | 1990 |
| dc.description | Undifferentiated carcinoma of nasopharyngeal type (UCNT) is a geographically endemic, Epstein-Barr virus-related carcinoma of epidermoid origin with reported 5-year survival rates of 15%–40% when treated with radiotherapy alone. Although UCNT can be well controlled locally by radiation therapy, in advanced nodal stage N3 [International Union Against Cancer-American Joint Committee on Cancer (UICC-AJCC, 1987)] the survival rate is below 20%, primarily because of metastatic spread in 80% of the fatalities. We report a pilot study of 41 patients with nonmetastatic, locoregionally advanced disease (85% of the patients had a nodal status ≥ N2C-N3; 43% had T4 primaries), during which we used a combination of 100 mg of cisplatin/m<sup>2</sup> on day 1, 15 mg of bleomycin by intravenous push and 12 mg/m<sup>2</sup> by continuous infusion on days 1–5, and 70 mg of epirubicin/m<sup>2</sup> on day 1 every 21 days for three cycles before definitive radiation therapy with 70 Gy for 7 weeks. Twenty-seven of 41 patients (66%; 95% confidence interval = 52.5%–80.5%) achieved a clinical complete response, and 40 of 41 (98%) had a major objective response after chemotherapy. Two deaths were treatment related, but side effects were moderate, and the overall treatment sequence was feasible. At the end of radiation therapy, all 39 assessable patients were in complete response, with a median follow-up of 21+ months (>10–>31); 33 (80%) patients had no evidence of disease. We believe that such a complete response rate in a high-volume disease with the use of combined modality treatment indicates a therapeutic gain in UCNT. Researchers performing a multicenter international controlled trial will test this hypothesis and compare local control, disease-free, and overall survival of the therapeutic sequence presented here with radiotherapy alone. (J Natl Cancer Inst 82:616–620, 1990) |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Oxford University Press |
| Тема | Reports |
| Название | High Complete Response in Advanced Nasopharyngeal Carcinoma With Bleomycin, Epirubicin, and Cisplatin Before Radiotherapy |
| Тип | other |
| Electronic ISSN | 1460-2105 |
| Print ISSN | 0027-8874 |
| Журнал | JNCI: Journal of the National Cancer Institute |
| Том | 82 |
| Первая страница | 616 |
| Последняя страница | 620 |
| Аффилиация | Bachouchi Mounir; Department of Medicine Institut Gustave Roussy |
| Аффилиация | Cvitkovic Esteban; Department of Medicine Institut Gustave Roussy |
| Аффилиация | Azli Nasser; Department of Oncology, Benbadis Hospital |
| Аффилиация | Gasmi Jamal; Department of Medicine Institut Gustave Roussy |
| Аффилиация | Cortes-Funes Hernan; Oncology Service, 12 Octobre Hospital |
| Аффилиация | Boussen Hamouda; Department of Medicine, Institut Salah Azaiz |
| Аффилиация | Rahal Mohamed; Department of Oncology, Benbadis Hospital |
| Аффилиация | Kalifa Chantal; Department of Pediatrics Institut Gustave Roussy |
| Аффилиация | Schwaab Guy; Department of Head and Neck Surgery Institut Gustave Roussy |
| Аффилиация | Eschwege Francois; Department of Radiotherapy, Institut Gustave Roussy |
| Аффилиация | Wibault Pierre; Department of Radiotherapy, Institut Gustave Roussy |
| Аффилиация | Armand Jean Pierre; Department of Medicine Institut Gustave Roussy |
| Выпуск | 7 |
