| Автор | Lijinsky, William |
| Автор | Taylor, H. Wayne |
| Автор | Keefer, Larry K. |
| Дата выпуска | 1976 |
| dc.description | Groups of 30 male Sprague-Dawley rats were given 4-nitrosomorpholine-3,3,5,5-d<sub>4</sub> in their drinking water at concentrations of 0.35 and 0.07×10<sup>−3</sup> M for 30 weeks. Two similar groups of rats were simultaneously given unlabeled 4-nitrosomorpholine (NM) at the same molar concentrations; all animals were observed throughout their lives. Those receiving the α-deuteriumlabeled compound had significantly fewer liver tumors than did the corresponding animals receiving the unlabeled compound. The difference in potency appeared to be at least fivefold, a magnitude consistent with a primary kinetic isotope effect on the carcinogenic action of NM. Thus breakage of a bond linking a hydrogen (deuterium) atom with a carbon adjacent to the nitrosamino function may be involved in a rate-limiting step of carcinogenesis by NM. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Тема | Clinical and Laboratory Investigations on Animals |
| Название | Reduction of Rat Liver Carcinogenicity of α-Nitrosomorpholine by a-Deuterium Substitution<sup>2</sup> |
| Тип | research-article |
| DOI | 10.1093/jnci/57.6.1311 |
| Electronic ISSN | 1460-2105 |
| Print ISSN | 0027-8874 |
| Журнал | JNCI: Journal of the National Cancer Institute |
| Том | 57 |
| Первая страница | 1311 |
| Последняя страница | 1313 |
| Аффилиация | Lijinsky William; Biology Division, Oak Ridge National Laboratory |
| Аффилиация | Taylor H. Wayne; Biology Division, Oak Ridge National Laboratory |
| Аффилиация | Keefer Larry K.; Carcinogen Metabolism and Toxicology Branch, NCI, National Institutes of Health, PHS, U.S. Department of Health, Education, and Welfare |
| Выпуск | 6 |
