| Автор | Modlin, Robert L. |
| Автор | Segal, Gary P. |
| Автор | Hofman, Florence M. |
| Автор | Walley, Michael S. |
| Автор | Johnson, Royce H. |
| Автор | Taylor, Clive R. |
| Автор | Rea, Thomas H. |
| Дата выпуска | 1985 |
| dc.description | Immunohistochemical techniques using monoclonal antibodies to T lymphocyte subpopulations were used to characterize further the granulomas of disseminated coccidioidomycosis. Skin biopsy specimens from patients with disseminated coccidioidomycosis were studied and compared with tissues from experimentally infected mice. In human skin biopsy specimens and infected mouse tissues, discrete granulomata were seen in which T lymphocytes formed a peripheral mantle surrounding central aggregates of macrophages. This unusual pattern of granuloma formation may represent an ineffective host response because these individuals are unable to clear their infection. Because of the close similarity of immunopathology in both human and mouse infections, the mouse model should serve as a useful tool in elucidating the factors contributing to ineffective host responses in systemic fungal infections. |
| Формат | application.pdf |
| Издатель | The University of Chicago Press |
| Копирайт | © 1985 by The University of Chicago |
| Тема | Original Articles |
| Название | In Situ Localization of T Lymphocytes in Disseminated Coccidioidomycosis |
| Тип | research-article |
| DOI | 10.1093/infdis/151.2.314 |
| Electronic ISSN | 1537-6613 |
| Print ISSN | 0022-1899 |
| Журнал | The Journal of Infectious Diseases |
| Том | 151 |
| Первая страница | 314 |
| Последняя страница | 319 |
| Аффилиация | Section of Dermatology, University of Southern California School of Medicine; the Department of Pathology, University of Southern California, Los Angeles |
| Аффилиация | Infectious Diseases Section, Department of Medicine, V.A. Medical Center, Long Beach |
| Аффилиация | Department of Medicine, University of California School of Medicine, Irvine |
| Аффилиация | Section of Dermatology and Infectious Diseases, Department of Internal Medicine, Kern Medical Center, Bakersfield, California |
| Выпуск | 2 |
