| Автор | Munné, Santiago |
| Автор | Alikani, Mina |
| Автор | Cohen, Jacques |
| Дата выпуска | 1994 |
| dc.description | Monospermic cleavage-arrested human embryos were analysed by fluorescence in-situ hybridization using specific DNA probes for chromosomes X, Y and 18 simultaneously. Two groups of monospermic polyploid embryos could be distinguished: (i) embryos (n = 13) with only one large cell surrounded by smaller blastomere-sized extracellular fragments. These embryos were polyploid and frequently polyploid mosaic. (ii)Embryos developing from larger than normal oocytes were triploid or triploid mosaics (n = 4). Atypical morphology was not seen in eight other polyploid monospermic embryos. The atypical morphologies described here are quite rare, but are genetically uniform. Polyspermic embryos are the only other known example of a dual genetic-morphological abnormality |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Oxford University Press |
| Тема | in-situ hybridization |
| Тема | in-vitro fertilization |
| Тема | mosaicism |
| Тема | polyploidy |
| Тема | triploidy |
| Тема | Fertilization and early embryology |
| Название | Monospermic polyploidy and atypical embryo morphology |
| Тип | other |
| Electronic ISSN | 1460-2350 |
| Print ISSN | 0268-1161 |
| Журнал | Human Reproduction |
| Том | 9 |
| Первая страница | 506 |
| Последняя страница | 510 |
| Аффилиация | <sup>2</sup>The Gamete and Embryo Research Laboratory, Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, New York Hospital-Cornell University Medical Center P.O. Box 30, 1300 York Avenue, New York NY 10021, USA |
| Выпуск | 3 |
