| Автор | Wu, Qi |
| Автор | Brown, Mark R. |
| Дата выпуска | 2006 |
| dc.description | ▪ Abstract Insulin-like peptides (ILPs) exist in insects and are encoded by multigene families that are expressed in the brain and other tissues. Upon secretion, these peptides likely serve as hormones, neurotransmitters, and growth factors, but to date, few direct functions have been demonstrated. In Drosophila melanogaster, molecular genetic studies have revealed elements of a conserved insulin signaling pathway, and as in other animal models, it appears to play a key role in metabolism, growth, reproduction, and aging. This review offers (a) an integrated summary of the efforts to characterize the distribution of ILPs in insects and to define this pathway and its functions in Drosophila and (b) a few considerations for future studies of ILP endocrinology in insects. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | SIGNALING AND FUNCTION OF INSULIN-LIKE PEPTIDES IN INSECTS |
| DOI | 10.1146/annurev.ento.51.110104.151011 |
| Print ISSN | 0066-4170 |
| Журнал | Annual Review of Entomology |
| Том | 51 |
| Первая страница | 1 |
| Последняя страница | 24 |
| Аффилиация | Wu, Qi; Department of Cellular Biology, 2Biomedical and Health Sciences Institute, 3Department of Entomology, University of Georgia, Athens, Georgia; email: qiwu@uga.edu ; mbrown@bugs.ent.uga.edu |
