| Автор | KUMAOKA, SOICHI |
| Автор | TAKATANI, OSAMU |
| Автор | YOSHIDA, MINORU |
| Автор | MIURA, SHIGETO |
| Автор | TAKAO, TETSUTO |
| Автор | HAMANAKA, YÜJI |
| Автор | IZUO, MASARU |
| Автор | OKADA, TADAKAZU |
| Дата выпуска | 1974 |
| dc.description | A new orally active anti-estrogenic steroid, 2α,3α-epithio-5α-androstan-17β-yl 1-methoxycyclopentyl ether (10364-S) was given to 41 advanced breast cancer patients. Most patients were given a daily dose of 20 mg. The study was preliminary and not a controlled trial using an already proven androgenic steroid. The remission rate on giving this compound to advanced breast cancer was 11/41 or 26.8% and the average duration of the remission was 10.5 months.Hoarseness (8/41, 19.5%) and hirsutism (5/41, 12.2%) were relatively often seen as virilizing side effects. No unfavorable effects on the hematopoietic organs, the liver or on calcium metabolism were recognized in the study. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © 1974 JAPANESE JOURNAL OF CLINICAL ONCOLOGY |
| Тема | ORIGINALS |
| Название | 2α,3α-Epithio-5α-androstan-17β-yl 1-Methoxycyclopentyl Ether in the Treatment of Advanced Breast Cancer —A Preliminary Clinical Trial— |
| Тип | research-article |
| Electronic ISSN | 1465-3621 |
| Print ISSN | 0368-2811 |
| Журнал | Japanese Journal of Clinical Oncology |
| Том | 4 |
| Первая страница | 65 |
| Последняя страница | 68 |
| Аффилиация | KUMAOKA SOICHI; National Cancer Center Research Institute |
| Аффилиация | TAKATANI OSAMU; National Cancer Center Hospital |
| Аффилиация | YOSHIDA MINORU; Aichi Cancer Center Hospital |
| Аффилиация | MIURA SHIGETO; Aichi Cancer Center Hospital |
| Аффилиация | TAKAO TETSUTO; First Department of Surgery, Osaka University Medical School |
| Аффилиация | HAMANAKA YÜJI; First Department of Surgery, Osaka University Medical School |
| Аффилиация | IZUO MASARU; Department of Surgery, Gunma University, School of Medicine |
| Аффилиация | OKADA TADAKAZU; Department of Surgery, Gunma University, School of Medicine |
| Выпуск | 1 |
