| Автор | Hitachi, Prince Masahito |
| Автор | Yamada, Kiyomi |
| Автор | Takayama, Shozo |
| Дата выпуска | 1975 |
| dc.description | SummaryAll the hepatocarcinogens administered to rats markedly increased the mitotic rate in the liver. Except for ɑ-benzene hexachloride and nitrosobutylurea, the nonhepatocarcinogens did not appreciably increase the mitotic rate. Cytogenetic analyses on the ploidy rate and chromosome abnormalities evidenced qualitative differences among mitotic liver cells in animals treated with hepatocarcinogens and nonhepatocarcinogens. The active cell proliferation and chromosome changes in liver cells observed after the administration of hepatocarcinogenic substances may have some relation to an essential process in hepatocarcinogenesis. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Тема | Experimental Investigations on Animals |
| Название | Brief Communication: Cytologic Changes Induced in Rat Liver Cells by ShortTerm Exposure to Chemical Substances2 |
| Тип | research-article |
| DOI | 10.1093/jnci/54.5.1245 |
| Electronic ISSN | 1460-2105 |
| Print ISSN | 0027-8874 |
| Журнал | JNCI: Journal of the National Cancer Institute |
| Том | 54 |
| Первая страница | 1245 |
| Последняя страница | 1247 |
| Выпуск | 5 |
