| Автор | Wilk, Manfred |
| Автор | Girke, Wolfgang |
| Дата выпуска | 1972 |
| dc.description | SummaryAdsorbed aromatic compounds were relatively easily oxidized. As active intermediates, radical cations occurred which, in carcinogenic compounds, preferred electrephilic substitutions to further oxidation. Benzo[a]pyrene in an adsorbed state could be oxidized by iodine in the presence of pyrimidines and purines. Some of the many products formed by adenine and purine were isolated and investigated spectroscopically. A 7- (or 9-) benzo[a]pyrenylpurine formed, and 6-aminobenzo[a]pyrene was a degradation product. The significance of oneelectron oxidation as a possible primary step in chemical carcinogenesis is discussed. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Тема | Experimental Investigations on Animals |
| Название | Reactions Between Benzo[a]pyrene and Nucleobases by One-Electron Oxidation234 |
| Тип | research-article |
| DOI | 10.1093/jnci/49.6.1585 |
| Electronic ISSN | 1460-2105 |
| Print ISSN | 0027-8874 |
| Журнал | JNCI: Journal of the National Cancer Institute |
| Том | 49 |
| Первая страница | 1585 |
| Последняя страница | 1597 |
| Аффилиация | Institut für Organische Chemie der Universität, Frankfurt/Main, Germany |
| Выпуск | 6 |
