| Автор | WHEELDON, N.M. |
| Автор | MacDONALD, T.M. |
| Автор | PRASAD, N. |
| Автор | MACLEAN, D. |
| Автор | PEEBLES, L. |
| Автор | McDEVITT, D.G. |
| Дата выпуска | 1995 |
| dc.description | We compared the β<sub>1</sub>-selective adrenoceptor antagonists bisoprolol and atenolol in a double-blind, randomized crossover study. After 4 weeks placebo phase, 59 patients with essential hypertension received either 10 mg bisoprolol or 50 mg atenolol once daily for 8 weeks, increased if necessary (target BP ≤150/90 mmHg) to 20 and 100 mg, respectively, after 4 weeks. After asecond placebo phase, crossover occurred to the alternative drug. We measured resting systolicand diastolic blood pressures and heart rate at 24 h post-dose baseline and after 4 and 8 weeks treatment. Both drugssignificantly lowered systolic and diastolic blood pressures and heart rate at 8 weeks compared to baseline (all p <0.05). Bisoprololreduced heart ratesignificantly more than atenolol (p <0.01), but systolic and diastolic blood pressure changes were not different between the two drugs. There was no difference in patient acceptability of the drugs as assessed by visual analogue scale. Despite theoreticaland circumstantial evidence to suggest superiority of bisoprolol over atenolol, no significant difference between the two was found except for greater heart rate reduction with bisoprolol. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Oxford University Press |
| Тема | Articles |
| Название | A double-blind comparison of bisoprolol and atenolol in patients with essential hypertension |
| Тип | research-article |
| Electronic ISSN | 1464-3855 |
| Print ISSN | 0033-5614 |
| Журнал | Quarterly Journal of Mechanics and Applied Mathematics |
| Том | 88 |
| Первая страница | 565 |
| Последняя страница | 570 |
| Аффилиация | Hypertension Unit, University Department of Clinical Pharmacology, Ninewells Hospital and Medical SchoolDundee, UK |
| Выпуск | 8 |
