COMPARISON OF THE ANALGESIC EFFECT OF TEN NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
ISOMÄKI, HEIKKI; MARTIO, JUKKA; KAARELA, KALEVI; KAJANDER, AARO; KOOTA, KALEVI; LEHTINEN, KARI; LUUKKAINEN, REIJO; MARTIO, TUULIKKI; NISSILÄ, MARTTI; NUOTIO, PEKKA; SARNA, SEPPO; ISOMÄKI HEIKKI; Rheumatism Foundation Hospital; MARTIO JUKKA; Rheumatism Foundation Hospital; KAARELA KALEVI; Rheumatism Foundation Hospital; KAJANDER AARO; Rheumatism Foundation Hospital; KOOTA KALEVI; Rheumatism Foundation Hospital; LEHTINEN KARI; Rheumatism Foundation Hospital; LUUKKAINEN REIJO; Rheumatism Foundation Hospital; MARTIO TUULIKKI; Rheumatism Foundation Hospital; NISSILÄ MARTTI; Rheumatism Foundation Hospital; NUOTIO PEKKA; Rheumatism Foundation Hospital; SARNA SEPPO; Department of the Public Health, University of Helsinki
Журнал:
Rheumatology
Дата:
1984
Аннотация:
The analgesic effect of 10 anti-inflammatory drugs was compared using a single-blind method in 90 patients with rheumatoid arthritis. Each patient received two different drugs, for three days each and each drug was evaluated in 18 patients. After the trial, the patients considered which of the drugs they preferred.The greatest relief from pain was achieved by diclofenac, indomethacin, naproxen and tolfenamic acid, each of these being preferred by the majority of patients and being significantly (p>0.01) better than the least effective drugs ketoprofen and proquazone. Acetylsalicylic acid, azapropazone, carprofen and ibuprofen were considered intermediate in efficacy.
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