| Автор | Wijnholds, Jan |
| Автор | Philipsen, Sjaak |
| Автор | Pruzina, Sara |
| Автор | Fraser, Peter |
| Автор | Grosveld, Frank |
| Автор | AB, Geert |
| Дата выпуска | 1993 |
| dc.description | We have examined the chicken Very Low Density Apolipoprotein II (apoVLDL II) gene locus in transgenic mice. A DNA fragment composed of the transcribed region, 16 kb of 5′ flanking and 400 bp of 3′ flanking sequences contained all the information sufficient for estrogen-inducible, liver-specific expression of the apoVLDL II gene. The far-upstream region contains a Negative Regulating Element coinciding with a DNaseihypersensitive site at −11 kb. in transgenic mice, the NRE at −11 kb is used for downregulating the expression to a lower maximum level. The NRE might be used for modulating apoVLDL II gene expression, and may be involved in the rapid shut-down of the expression after hormone removal. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © 1993 Oxford University Press |
| Тема | MOLECULAR BIOLOGY |
| Название | Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice |
| Тип | research-article |
| Electronic ISSN | 1362-4962 |
| Print ISSN | 0305-1048 |
| Журнал | Nucleic Acids Research |
| Том | 21 |
| Первая страница | 1629 |
| Последняя страница | 1635 |
| Аффилиация | Laboratory of Biochemistry, Groningen UniversityNijenborgh 4, 9747 AG Groningen, The Netherlands |
| Аффилиация | Philipsen Sjaak; Laboratory of Gene Structure and Expression, National Institute for Medical Research |
| Аффилиация | Pruzina Sara; Laboratory of Gene Structure and Expression, National Institute for Medical Research |
| Аффилиация | Fraser Peter; Laboratory of Gene Structure and Expression, National Institute for Medical Research |
| Аффилиация | Grosveld Frank; Laboratory of Gene Structure and Expression, National Institute for Medical Research |
| Выпуск | 7 |
