Obesity, because of its association with hypertension, hyperlipidemia and diabetes, has been identified as an important risk factor for cardiovascular disease. Approximately 16.7 million workers are more than 20% above their desired weight. This paper focuses on the implementation and cost-effectiveness of a weight loss awareness campaign conducted at worksites. ‘Lighten Up’ was a 5-week, self-help weight loss campaign offered free through the Pawtucket Heart Health Program. Worksite volunteer coordinators, with the assistance of the PHHP staff, were responsible for implementing the campaign in their respedive worksites. Five hundred and twelve employees from 22 companies lost a total of 1,818 pounds; an average weight loss of 3.55 pounds per person. Program costs, including PHHP personnel time, amounted to $0.81 spent per pound lost. The data suggests that the PHHP ‘Lighten Up’ campaign is an effective worksite weight loss strategy for a large group of people.