| Автор | Chevret, s. |
| Автор | Kirstetter, M. |
| Автор | Mariotti, M. |
| Автор | Lefrère, F. |
| Автор | Frottier, J. |
| Автор | Lefrère, J .-J. |
| Дата выпуска | 1994 |
| dc.description | To evaluate the prognostic value of provirus copy number through quantitative DNA polymerase chain reaction (PCR) in early stages of human immunodeficiency virus type 1 (HIV-1) infection, 42 untreated and asymptomatic HIV-L-seropositive subjects with baseline CD4<sup>+</sup> cell counts >200 × 10<sup>6</sup>/L were included in a prospective study and followed over a median of 27 months. Disease progression was defined as decrease in CD4<sup>+</sup> cells to <200 (14 events). At enrollment, provirus copy number was associated with CD4<sup>+</sup> cell count and percentage, serum IgA, and p24 antigenemia. Elevated provirus copy number above 20 allowed identification of patients at high risk of a subsequently decreasing CD4<sup>+</sup> cell count, even after adjusting for baseline CD4<sup>+</sup> cell count (P = .003). Measuring provirus copy number by PCR at early stages of HIV-1 infection could offer a useful early means to predict progression to AIDS. |
| Формат | application.pdf |
| Издатель | The University of Chicago Press |
| Копирайт | © 1994 by The University of Chicago |
| Тема | Concise Communications |
| Название | Provirus Copy Number to Predict Disease Progression in Asymptomatic Human Immunodeficiency Virus Type 1 Infection |
| Тип | research-article |
| DOI | 10.1093/infdis/169.4.882 |
| Electronic ISSN | 1537-6613 |
| Print ISSN | 0022-1899 |
| Журнал | The Journal of Infectious Diseases |
| Том | 169 |
| Первая страница | 882 |
| Последняя страница | 885 |
| Аффилиация | Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis |
| Аффилиация | Service d'Infectiologie and Institut National de Transfusion Sanguine, Hôpital Saint-Antoine, Paris, France |
| Выпуск | 4 |
