| Автор | Ireton, Keith |
| Автор | Cossart, Pascale |
| Дата выпуска | 1997 |
| dc.description | ▪ Abstract Listeria monocytogenes is a pathogenic bacterium that induces its own uptake into mammalian cells, and spreads from one cell to another by an actin-based motility process. Entry into host cells involves the bacterial surface proteins InlA (internalin) and InlB. The receptor for InlA is the cell adhesion molecule E-cadherin. InlB-mediated entry requires activation of the host protein phosphoinositide (PI) 3-kinase, probably in response to engagement of a receptor. Actin-based movement of L. monocytogenes is mediated by the bacterial surface protein ActA. The N-terminal region of this protein is necessary and sufficient for polymerization of host cell actin. Other host proteins involved in bacterial motility include profilin, Vasodilator-Stimulated Phosphoprotein (VASP), the Arp2/Arp3 complex, and cofilin. Studies of entry and intracellular movement of L. monocytogenes could lead to a better understanding of receptor-ligand signaling and dynamics of actin polymerization in mammalian cells. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | HOST-PATHOGEN INTERACTIONS DURING ENTRY AND ACTIN-BASED MOVEMENT OF LISTERIA MONOCYTOGENES |
| DOI | 10.1146/annurev.genet.31.1.113 |
| Print ISSN | 0066-4197 |
| Журнал | Annual Review of Genetics |
| Том | 31 |
| Первая страница | 113 |
| Последняя страница | 138 |
| Аффилиация | Ireton, Keith; Unité des Interactions Bactéries-Cellules, Institut Pasteur, 28 rue du Dr. Roux, Paris Cedex 15, 75724 France; e-mail: pcossart@pasteur.fr |
